S,8 S,9 S,10 R,13 S,14 S,17 S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1 H-cyclopenta[ a]phenanthren-3-yl] hydrogen sulfate
Pregn-sulf; Pregnenolone monosulfate; Pregnenolone hydrogen sulfate; Pregnenolone 3β-sulfate; 5-Pregnen-3β-ol-20-one sulfate; (3β)-3-(Sulfooxy)pregn-5-en-20-one; 5-Pregnen-3β-sulfate-20-one; 20-Oxo-5-pregnen-3β-yl sulfate
C 21 H 32 O 5 S
Molar mass 396.54 g·mol
Except where otherwise noted, data are given for materials in their
(at 25 °C [77 °F], 100 kPa).
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Pregnenolone sulfate ( PS, PREGS), also known as pregn-5-en-3β-ol-20-one 3β-sulfate, is an endogenous excitatory neurosteroid that is synthesized from pregnenolone.  It is known to have  cognitive and memory-enhancing, antidepressant, anxiogenic, and proconvulsant effects. 
Biological activity [ edit ]
Pregnenolone sulfate is a neurosteroid with excitatory effects in the brain, acting as a potent
negative allosteric modulator of the GABA and a weak A receptor positive allosteric modulator of the NMDA receptor.  To a lesser extent, it also acts as a negative allosteric modulator of the  AMPA, kainate, and glycine receptors,  and may interact with the  nACh receptors as well. In addition to its effects on  ligand-gated ion channels, pregnenolone sulfate is an agonist of the sigma receptor, as well as an  activator of the TRPM1 and TRPM3 channels. It may also interact with  potassium channels and voltage-gated sodium channels and has been found to inhibit  voltage-gated calcium channels. 
Additional images [ edit ]
, with pregnenolone, the precursor of pregnenolone sulfate, at bottom left.
See also [ edit ]
References [ edit ]