Premenstrual dysphoric disorder

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Premenstrual dysphoric disorder
Other namesLate luteal phase dysphoric disorder
SpecialtyPsychiatry
SymptomsSevere mood swings, depression, irritability, agitation, uneasiness, change in appetite, feeling tired, anxiety, anger, swelling, bruising, insomnia/hypersomnia, breast tenderness, decreased interest in usual /social activities, reduced interest in sexual activity, heart palpitations, difficulty in concentration.
Usual onsetearly teens
Duration6 days – 3 weeks of cycle
Causesunknown
Risk factorsFamily history
Diagnostic methodbased on symptoms & criteria
Differential diagnosisPremenstrual syndrome, depression, anxiety disorder
Treatmentmedication, counselling, lifestyle change, surgery
Medicationhormone treatment, SSRI’s,
Frequency1.8–5.8% of menstruating women

Premenstrual dysphoric disorder (PMDD) is a severe and disabling form of premenstrual syndrome affecting 1.8–5.8% of menstruating women.[1] The disorder consists of a variety of affective, behavioral and somatic symptoms that recur monthly during the luteal phase of the menstrual cycle.[2][3] It affects women from their early teens up until menopause, excluding those with hypothalamic amenorrhea or during pregnancy and breastfeeding.[4] Those with PMDD are at higher risk of suicide, with rates of suicidal thoughts 2.8 times higher, history of suicidal planning 4.15 times, and suicide attempts 3.3 times.[5]

The emotional effects of premenstrual dysphoric disorder are theorized to be the result of severe gonadal steroid fluctuations, as they cause dysregulation of serotonin uptake and transmission, and potentially calcium regulation, circadian rhythm, BDNF, the HPA-axis and immune function as well.[6]

In 2017, researchers at the National Institutes of Health discovered that people with PMDD have genetic changes that make their cells overreact to estrogen and progesterone. They believe this overreaction may be responsible for PMDD symptoms.[7]

Some studies have suggested that those with PMDD are more at risk of developing postpartum depression after pregnancy, but other evidence has been found to suggest against that notion.[8] PMDD was added to the list of depressive disorders in the Diagnostic and Statistical Manual of Mental Disorders in 2013.[1] It has 11 main symptoms, and a person has to exhibit at least five to qualify for PMDD.[6] Roughly 20% of menstruating people have some symptoms of PMDD, but either have less than five or do not have functional impairment.[9]

Treatment is often with antidepressants such as selective serotonin reuptake inhibitors (SSRIs) or hormone treatment (ovulation suppression) using birth control pills and GnRH analogues.[3] SSRIs are the most common treatment, as they tend to improve both the physical and emotional symptoms as well as the general behavior and functionality of the person, however the clinician must determine the best treatment based on the subjects criteria markers, given if the subject doesn’t display markers outside the luteal phases or menses.[3]

Signs and symptoms[edit]

Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS). Like PMS, premenstrual dysphoric disorder follows a predictable, cyclic pattern. Symptoms begin in the late luteal phase of the menstrual cycle (after ovulation) and end shortly after menstruation begins.[10] On average, the symptoms last six days but can start up to two weeks before menses, meaning symptoms can be felt for up to three weeks out of a cycle. Severe symptoms can begin and worsen until the onset of menstruation, with many not feeling relief until a few days after menstruation ends. The most intense symptoms occurring in the week and days leading up to the first day of menstrual blood flow.[2] The symptoms usually cease shortly after the start of the menstrual period or a few days after it ending.[3][11] The onset of symptoms only during or around the luteal phase is key for diagnosing someone with PMDD rather than any other mood disorders.[4]

The symptoms can be physical or emotional, but mood symptoms must be present for the diagnosis.[10] Those with PMDD may have thoughts of suicide.[12] A mood log in which a person records mood patterns over time may help direct.[4]

The International Society for the Study of Premenstrual Disorders (ISPMD) defines two categories of premenstrual disorders: core PMD and variant PMD.[4]

Core PMD has six characteristics, all mainly focusing on the cyclical nature of PMDD and its typical onset pre-menses tracked over the course of more than two menstrual cycles. The four classified Variant PMDs involve more unexpected variables that cause the onset of premenstrual distress; such as, PMD with absent menstruation or premenstrual exacerbation, wherein the symptoms of another preexisting psychological disorder may be heightened as a result of PMDD onset.[4]

Associated conditions[edit]

Bipolar depression, anxiety disorders, and other Axis I disorders are more common in those with PMDD.[13] In those with PMDD, there is a 40% lifetime incidence of various psychiatric disorders such as generalized anxiety disorder, seasonal affective disorder, and major depressive disorder.[3]

Cause[edit]

PMDD mood symptoms are only present in menstruating women. Thus, symptoms do not occur during pregnancy and after menopause. Other mood disorders typically persist across all reproductive life events and are independent of a person's menstrual cycle or lack thereof.[14]

The most agreed-upon possibilities for what causes PMDD currently are heightened sensitivity to fluctuating levels of certain hormones (i.e. the reproductive hormones), environmental stress, and genetic predisposition.[4] The sex steroids—estrogen and progesterone—are neuroactive; they have been noted in rat models to be involved in serotonin pathways.[4] Serotonin is involved in mood regulation alongside estrogen, whose receptors are found in the prefrontal cortex and hippocampus—the regions most known for their involvement in regulating one's mood and cognition overall.[2][4]

While the timing of symptoms suggests hormonal fluctuations as the cause of PMDD, a demonstrable hormonal imbalance in people with PMDD has not been identified. In fact, levels of reproductive hormones and their metabolites in people with and without PMDD are indistinguishable.[15][16][17] It is instead hypothesized that people with PMDD are more sensitive to normal levels of hormone fluctuations, predominantly estrogen and progesterone, which produces biochemical events in the nervous system that cause the premenstrual symptoms.[17] These symptoms are more predominant in people who have a predisposition to the disorder.[10]

It is apparent that the premenstrual disorders are biologically driven and are not only psychological or cultural phenomena. PMDD has been reported by menstruating people worldwide, indicating a biological basis that is not geographically selective.[2] Most psychologists infer that this disorder is caused by both a reaction to hormone flux and also genetic components. There is evidence of heritability of (retrospectively-reported) premenstrual symptoms from several twin and family studies done in the 1990s, with the heritability of PMDD proving to be about 56%.[18][19][20]

Disorders of this nature are often caused by a mix of both environmental and biological factors. Environmental stressors have also been found to prospectively increase risk for PMDD symptoms.[21][22] Genetics do not operate in a vacuum: environmental components such as stress, hormonal fluctuation, and epigenetics play a key role in the pathology and onset of the disorder.[23] Some studies have noted evidence of interpersonal trauma (domestic violence, physical or emotional trauma, or substance abuse) or seasonal changes (making PMDD potentially comorbid with Seasonal Affective Disorder) having an impact on PMDD risk.[3][24] But the most common pre-existing disorder found in those diagnosed with PMDD is major depression, wherein they either actually had it or were misdiagnosed when they should have only been diagnosed with PMDD.[24] The last environmental factor is primarily sociological: the sociocultural aspects of being female, performing female gender roles, and stress from engaging in female sexual activity.[1]

Genetic Factors

While whether or not this disorder has a specific genetic basis is still being discussed in the academic community and the possible genetic factors contributing to PMDD have yet to be thoroughly researched, there has recently been multiple genetic factors identified that contribute to the moodiness, depression, irritability, increased appetite, trouble sleeping, acne, fluid retention, headaches, nausea, and other symptoms that are all associated with this disorder.

One case that has been identified of a gene that may be linked to PMDD is in a study in mice that has shown evidence that a polymorphism of the brain-derived neurotrophic factor gene (BDNF), a gene that helps support neurons in their function and survival in the brain by creating a protein that helps in the growth, maturation, and maintenance of these cells, may play a role in causing PMDD symptoms. This is because the result of this polymorphism mimics the hallmarks of PMDD: volatile moods, depression and irritability centered around the menstrual cycle. This gene has been studied extensively in its association with depression and, promisingly for PMDD research, mice homozygous for the BDNF polymorphism exhibited anxiety-like traits that fluctuated and changed around the mice’s estrus, analogous to the human’s menstruation, therefore mimicking some of the symptoms of PMDD.[25]

By comparing the genomes of lymphoblastoid cells in mice and people with and without PMDD, two common epigenetic biomarkers, which are both linked to postpartum depression were found that transcend both species and cell types. Two of these loci were HP1BP3 and TTC9B. The exact functions of these loci are currently unknown, however, bioinformatics analysis suggests that both loci may be involved in mediating synaptic plasticity as well as estrogen signaling.[26] These loci were most notable because they were able to correctly identify whether a person would develop PPMD with 87% accuracy based on differences in methylation. These biomarkers were also important in that they could be used to segregate postpartum depression status in people who became depressed during pregnancy and continued to be depressed after giving birth during the postpartum time period with 88% accuracy, meaning that the biomarkers may also be helpful in discovering the likelihood of a person developing postpartum depression.[27][25]

Another study has shown that people with PMDD have dysregulation of the ESC/E(Z) complex. This leads to the body having an abnormal response to ovarian steroids and to the person having some of the symptoms of PMDD.[27] The G/G genotype of HTR1A (rs6295), a serotonin receptor that plays a role in regulating dopamine levels in the brain, has been associated with poor working memory and worsened cognitive function during the premenstrual phase for people with PMDD as well, a less common symptom of the disorder. The G/G genotype specifically plays a role in PMDD because this genotype reduces serotonin neurotransmission and is more common in individuals with major depressive disorder. This gene may therefore give insight into the mechanism through which some people with PMDD experience their symptoms.[28]

Risk for PMDD is also associated with genetic variation of ESR1, the estrogen receptor alpha gene. Specifically, those with PMDD were observed to have four single nucleotide polymorphisms, a variation in a single nucleotide in a genetic sequence, in intron 4 of ESR1. This association was only observed in individuals with a Val/Val genotype of COMT, the gene that codes for an enzyme that degrades several catecholamines, which are hormones made by the adrenal gland. One such catecholamine that this enzyme degrades that is particularly important to PMDD is dopamine. The Val/Val genotype of COMT renders it over efficient, leading to dopamine deficiency. This provides a genetic basis to explain some of the symptoms of PMDD that affect mood such as depression, irritability, and mood swings.[29] Highly recurrent copy number variations, a phenomena in which sections of the genome are repeated in numbers that vary among individuals, in GABRB2, a gene that codes for a brain receptor that plays a role in regulating stress responses, cognitive function, and energy regulation among other things, have also been found to be associated with both PMDD and schizophrenia. This is evidence that both of these neuropsychiatric disorders share some genetic basis.[30]

Relationship to pregnancy[edit]

People with PMDD usually see their symptoms disappear while they are pregnant. Premenstrual dysphoric disorder is primarily a mood disorder that is associated with onset of menstruation; pregnancy, menopause, and hysterectomies all cause menstruation to cease, thereby stopping the proposed sex steroid-/serotonin-caused symptoms from occurring.[31][32] Although one might expect a higher rate of postpartum depression among those with PMDD, a large study of women with prospectively-confirmed PMDD did not find a higher prevalence of postpartum depression than in controls.[8][32] If a person had experienced PPD beforehand, there was found to be a less-than 12% chance of PMDD pathology emerging—hardly any differentiation from the regular population of those who have never experienced postpartum depression.[32] However, PMDD symptoms can get worse following pregnancy, or other associated events such as birth and miscarriage.[12]

Menopause launches a person into an associated mood disorder called climacteric depression.[8] The permanent stopping of the menstrual cycle causes a myriad of physiological and psychological symptoms and issues, all associated with the natural estrogen deficiency post-menopause.[8]

Diagnosis[edit]

Diagnostic criteria for PMDD are provided by a number of expert medical guides. Diagnosis can be supported by having women who are seeking treatment for PMDD use a daily charting method to record their symptoms.[4] Daily charting helps to distinguish when mood disturbances are experienced and allows PMDD to be more easily distinguished from other mood disorders. With PMDD, mood symptoms are present only during the luteal phase, or last two weeks, of the menstrual cycle.[10] While PMDD mood symptoms are of a cyclical nature, other mood disorders are variable or constant over time. Although there is a lack of consensus on the most efficient instrument by which to confirm a PMDD diagnosis, several validated scales for recording premenstrual symptoms include the Calendar of Premenstrual Experiences (COPE), Daily Record of Severity of Problems (DRSP), and Prospective Record of the Severity of Menstruation (PRISM).[33][34] In the context of research, standardized numerical cutoffs are often applied to verify the diagnosis.[33] The difficulty of diagnosing PMDD is one reason that it can be challenging for lawyers to cite the disorder as a defence of crime, in the very rare cases where PMDD is allegedly associated with criminal violence.[35]

DSM-5[edit]

The DSM-5 which established seven criteria (A through G) for the diagnosis of PMDD.[1] There is overlap between the criteria for PMDD in the DSM-5 and the criteria found in the Daily Record of Severity of Problems (DRSP).[33][34]

According to the DSM-5, a diagnosis of PMDD requires the presence of at least five of these symptoms with one of the symptoms being numbers 1-4.[1] These symptoms should occur during the week before menses and remit after initiation of menses. In order to meet criteria for the diagnosis, the symptoms should be charted prospectively for two consecutive ovulation cycles in order to confirm a temporal and cyclical nature of the symptoms. The symptoms should also be severe enough to affect normal work, school, social activities, and/or relationships with others.[1]

The symptoms of Criteria A-C must have been met for most menstrual cycles that occurred in the preceding year, and have to have affected normal functioning to some degree (Criterion D).

Criterion A: During most menstrual cycles throughout the past year, at least 5 of the following 11 symptoms (especially including at least 1 of the first 4 listed) must be present in the final week before the onset of menses, must start to improve within a few days after the onset of menses, and become minimal or absent in the week post-menses:[1]

  1. Marked lability (e.g., mood swings)
  2. Marked irritability or anger
  3. Markedly depressed mood
  4. Marked anxiety and tension
  5. Decreased interest in usual activities
  6. Difficulty in concentration
  7. Lethargy and marked lack of energy
  8. Marked change in appetite (e.g., overeating or specific food cravings)
  9. Hypersomnia or insomnia
  10. Feeling overwhelmed or out of control
  11. Physical symptoms (e.g., breast tenderness or swelling, joint or muscle pain, a sensation of bloating and weight gain)[1][3]

Criterion B: One (or more) of the following symptoms must be present:[1]

  1. Marked affective lability (e.g., mood swings, feeling suddenly sad or tearful, or increased sensitivity to rejection)
  2. Marked irritability or anger or increased interpersonal conflicts
  3. Marked depressed mood, feelings of hopelessness, or self-deprecating thoughts
  4. Marked anxiety, tension, and/or feelings of being keyed up or on edge

Criterion C: One (or more) of the following symptoms must be present additionally, to reach a total of 5 symptoms when combined with present symptoms from Criterion B above:[1]

  1. Decreased interest in usual activities (e.g., work, school, friends, hobbies).
  2. Subjective difficulty in concentration.
  3. Lethargy, easy fatigability, or marked lack of energy.
  4. Marked change in appetite; overeating; or specific food cravings.
  5. Hypersomnia or insomnia.
  6. A sense of being overwhelmed or out of control.
  7. Physical symptoms such as breast tenderness or swelling, joint or muscle pain, a sensation of "bloating," or weight gain.

Criterion D: The symptoms observed in Criteria A-C are associated with clinically significant distress or interference with work, school, usual social activities, or relationships with others (e.g., avoidance of social activities; decreased productivity and efficiency at work, school, or home).[1]

  • Clinically significant distress is not defined explicitly by the DSM-IV, where it has been critiqued by multiple scholars as being too vague, and potentially detrimental for those who have symptoms of depression, anxiety, or other mood disorders because they do not meet the clinical significance requirement.[36][37]

Criterion E: The disturbance is not merely an exacerbation of the symptoms of another disorder, such as major depressive disorder, panic disorder, persistent depressive disorder (Dysthymia), or a personality disorder—although it may co-occur with any of these disorders.[1]

Criterion F: Criterion A should be confirmed by prospective daily ratings during at least two symptomatic cycles. The diagnosis may be made provisionally prior to this confirmation.[1]

Criterion G: The symptoms are not attributable to the physiological effects of a substance (e.g., drug abuse, a medication, other treatments) or another medical condition (e.g., hyperthyroidism).[1]

ICD 11[edit]

Diagnostic criteria for PMDD are also provided by the 2016 World Health Organization's International Classification of Diseases (ICD-11-CM):[38][39]

GA34.41 Premenstrual dysphoric disorder

Description

During a majority of menstrual cycles within the past year, a pattern of mood symptoms (depressed mood, irritability), somatic symptoms (lethargy, joint pain, overeating), or cognitive symptoms (concentration difficulties, forgetfulness) that begin several days before the onset of menses, start to improve within a few days after the onset of menses, and then become minimal or absent within approximately 1 week following the onset of menses. The temporal relationship of the symptoms and luteal and menstrual phases of the cycle may be confirmed by a prospective symptom diary. The symptoms are severe enough to cause significant distress or significant impairment in personal, family, social, educational, occupational or other important areas of functioning and do not represent the exacerbation of a mental disorder.

Early drafts of the ICD did not recognize PMDD as a separate condition.[40] In the World Health Organisation's classification system, the International Classification of Diseases (ICD-11), PMDD is listed as a "disease of the genitourinary system".[41]

Other[edit]

Other organizations that have published diagnostic criteria for PMDD include the Royal College of Obstetricians and Gynecologists and the International Society for the Study of Premenstrual Disorders (ISPMD).[42][38] The ISPMD was a consensus group established by an international multidisciplinary group of experts. The group's diagnostic criteria for PMDD focuses on the cyclic nature of the symptoms occurring during the luteal phase of the menstrual cycle, as well as the symptoms being absent after menstruation and before ovulation and causing significant impairment. The ISPMD diagnostic criteria for PMDD do not specify symptom characteristics or number of symptoms.[42]

In 2003 the Committee for Proprietary Medicinal Products required the manufacturer of fluoxetine to remove PMDD from the list of indications in Europe.[43] In Australia, PMDD is recognized by the Therapeutic Goods Administration. However, antidepressants are not reimbursed for PMDD under the Pharmaceutical Benefits Scheme.[44]

Differential diagnosis[edit]

In addition to Axis I disorders, several other medical illnesses such as chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, and migraine disorder may present symptoms similar or identical to those of PMDD.

The symptoms which coincide with mood disorders, i.e. major depressive disorder or bipolar disorder, may worsen during the premenstrual period and thus may mimic PMDD. This phenomenon is known as premenstrual exacerbation (PME) and refers to the worsening of mood disorder symptoms during the premenstrual phase. An estimated 40% of those who seek treatment for PMDD are found to not have PMDD, but rather a PME of an underlying mood disorder.[45]

Treatment[edit]

Medication[edit]

Several medications have received empirical support for the treatment of PMDD. Selective serotonin reuptake inhibitors (SSRIs) are the first-line medication.[10][46][47] The U.S. Food and Drug Administration (FDA) has approved four SSRIs for the treatment of PMDD: Fluoxetine (available as generic or as Prozac or Sarafem), sertraline (Zoloft), paroxetine (Paxil), and escitalopram oxalate (Lexapro).[48] Unlike treatments for depressive disorders, SSRIs do not need to be taken daily but instead can be taken only in the luteal phase or during PMDD symptoms.[3] This is because those who respond to SSRIs usually experience symptoms relief within 1–2 days.[49] Studies in rats suggest this rapid response to SSRIs is due to the elevation of the neuroactive progesterone metabolite allopregnanolone in the brain, rather than serotonin.[50][51] Luteal phase dosing can be started 14 days before menses and subsequently discontinued after start of menstrual flow.[48] Women taking SSRIs to ease PMDD generally report >50% alleviation in symptoms, which was significant improvement compared to placebo.[49]

Although less studied, SNRIs have also shown benefits for those with PMDD. In a randomized, controlled clinical trial of women with PMDD, 60% of the subjects taking venlafaxine (Effexor) improved, versus 35% on placebo. Improvement was noticed during the first treatment cycle with 80% symptom reduction.[52]

Another FDA approved treatment for PMDD is the oral contraceptive with ethinylestradiol and drospirenone (a novel progestin) taken on a 24-4 schedule (24 active pills, 4 inactive pills).[48] It has been shown that hormonal birth control containing drospirenone and low levels of estrogen helps relieve severe PMDD symptoms, for at least the first three months that it is used.[53] The idea behind using oral contraceptives is to suppress ovulation, therefore suppressing sex hormone fluctuations.

Another treatment, typically used when other options have failed, is injection of a gonadotropin-releasing hormone agonist.[54] These drugs create a temporary, drug-induced menopause-like condition. Addback of estradiol is recommended to prevent bone loss long-term; this generally necessitates the concurrent addback of progesterone to prevent estradiol-induced endometrial hyperplasia. Two landmark studies have demonstrated that the addback of estradiol or progesterone on top of GnRH agonists can cause a resurgence of PMDD symptoms but that this resurgence of symptoms remits after one month of stable addback.[55][56][57]

Psychotherapy[edit]

Cognitive behavioral therapy (CBT) has been shown to be effective for reducing premenstrual symptoms in women with (retrospectively-reported) PMS.[58] CBT is an evidence-based approach for treating depression and focuses on the link between mood, thoughts, and actions to help people address current issues and symptoms. When CBT was compared to SSRI alone or in combination with SSRI, groups receiving CBT had significant improvement of PMS symptoms.[58] Through the practice of CBT, people are better able to recognize and modify recurrent issues as well as thought and behavior patterns that interfere with functioning well or that make depressive symptoms worse. However, a recent meta-analysis suggests that existing psychotherapies may be primarily useful for reducing impairment (rather than symptom severity) in PMDD.[58]

Surgery[edit]

When drug-based treatments are ineffective or produce significant side effects, then removing the ovaries through oophorectomy can produce an immediate and permanent cure.[31] Typically, the uterus is removed during the same surgery, and the woman is prescribed a low-dose estrogen patch to reduce the symptoms produced by surgically induced menopause.[31]

Epidemiology[edit]

A majority of menstruating women have feeling of premenstrual symptoms to some degree, with 20-30% feeling enough symptoms to qualify for diagnosis of PMS and 3-8% of that group qualifying for the diagnosis of PMDD.[2][3] With only a small fraction feeling such intense distress linked to the onset of menstruation, any fear of social pathologizing of normal emotional and physical symptoms as a result of menstruation is unnecessary; PMDD is distinct, and having it included in the DSM-5 works to affirm that.[24]

History[edit]

In the 18th century, there were early accounts of weeping and other symptoms recurring almost every month,[59] and in 1822 Prichard gave this description: “Many women … display a degree of excitement and irritation … at the period of menstruation; these are chiefly females of very irritable habits. In such instances, … an unusual vehemence of feeling and expression is observed … or there is torpor and dejection of mind with a despondent disposition”. [60] In 1827 a German mother was acquitted of infanticide on the grounds of menstrual mood disorder.[61] Premenstrual tension was also described in the French literature of the early 19th century.[62] Nearly one hundred years later, there were American descriptions of a cyclic personality change appearing 10-14 days before, and ending dramatically at the menses.[63]

The diagnostic category was discussed in the DSM-IIIR (1987), in which the proposed condition was named "Late Luteal Phase Dysphoric Disorder" and was included in the appendix as a proposed diagnostic category needing further study.[64] Preparations for the DSM-IV led to debate about whether to keep the category at all, only keep it in the appendix, or remove it entirely; the reviewers determined that the condition was still too poorly studied and defined, so it was kept in the appendix but elaborated with diagnostic criteria to aid further study.[32][65]

As preparations were underway in 1998 for the DSM-IV-TR, the conversation changed, as Eli Lilly and Company paid for a large clinical trial of fluoxetine as a potential treatment for the condition that was then conducted by Canadian academics and published in the New England Journal of Medicine in 1995.[66] Other studies have been conducted as well, wherein all found that approximately 60% of women with PMDD in the trials improved with the drug; representatives from Lilly & Co. and the FDA participated in the discussion.[32][65]

Various strong stances were taken in said discussion. Sally Severino, a psychiatrist, argued that because symptoms were more prevalent in the United States, PMDD was a culture-bound syndrome and not a biological condition; she also claimed it unnecessarily pathologized the hormonal changes of the menstrual cycle.[32] Jean Endicott, another psychiatrist and chair of the committee, has argued that it was a valid condition from which women suffer and should be diagnosed and treated, and has claimed that if the symptoms were felt by males, far more effort and research would have been done by that moment. In the end the committee kept PMDD in the appendix.[32]

The decision has been criticized as being driven by Lilly's financial interests, and possibly by financial interests of members of the committee who had received funding from Lilly.[32] Paula Caplan, a psychologist who had served on the committee for the DSM-IV, noted at the time of the DSM-IV-TR decision that there was evidence that calcium supplements could treat PMDD but the committee gave it no attention. She had also claimed that the diagnostic category is harmful to women with PMDD, leading them to believe they are mentally ill, and potentially leading others to mistrust them in situations as important as job promotions or child custody cases.[32] She has called PMDD a fake disorder.[67] Nada Stotland has expressed concern that women with PMDD may actually have a more serious condition like major depressive disorder or may be facing difficult circumstances—such domestic abuse—and therefore may have their true issues remain undiagnosed and mismanaged if their gynecologist diagnoses them with PMDD and gives them drugs to treat it.[32]

The validity of PMDD was once more heavily debated when it came time to create the DSM-5 in 2008.[68][69] In the end it was moved out of the appendix and into the main text as a formal category. A review in the Journal of Clinical Psychiatry published in 2014 examined the arguments against inclusion, which it summarized as:

  1. the PMDD label will harm women economically, politically, legally, and domestically;
  2. there is no equivalent hormone-based medical label for males;
  3. the research on PMDD is faulty;
  4. PMDD is a culture-bound condition;
  5. PMDD is due to situational, rather than biological, factors; and
  6. PMDD was fabricated by pharmaceutical companies for financial gain.[70]

Each argument was addressed and researchers found:

  1. No evidence of harm;
  2. no equivalent hormone-driven disorder has been discovered in men despite research seeking it;
  3. the research base has matured and many more reputable studies have been performed;
  4. several cases of PMDD have been reported or identified;
  5. a small minority of women do have the condition; and
  6. while there has been financial conflict of interest, it has not made the available research unusable.[2][70]

It concluded that women have historically been under-treated and told that they were making their symptoms up, and that the formal diagnostic criteria would spur more funding, research, diagnosis and treatment for women with PMDD.[70]

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