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A preprohormone is the precursor protein to one or more prohormones, which are in turn precursors to peptide hormones.[1] In general, the protein consists of the amino acid chain that is created by the hormone-secreting cell, before any changes have been made to it. It contains a signal peptide, the hormone(s) itself (themselves), and intervening amino acids. Before the hormone is released from the cell, the signal peptide and other amino acids are removed.[2][3]


  1. ^ Voet, Donald; Voet, Judith (2010). Biochemistry (4th ed.). Hoboken, NJ: John Wiley & Sons. p. 675. ISBN 9780470570951.
  2. ^ "Introduction to Endocrine Physiology". University of Washington. Retrieved 17 November 2017.
  3. ^ Owens, Anthony (23 June 2017). "Prohormones: Effects, Risks, and Legality". Retrieved 17 November 2017.