Prime editing

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Prime editing is an early-stage experimental genome editing technique that has received mainstream press attention because of the possibility that it might potentially be used to cure many human genetic diseases.[1][2][3] The technique uses methods similar to the earlier CRISPR technique, but claims higher accuracy.[4][5] As of 2019, the technique is still only a laboratory proof of concept, not a therapeutic technique.[6][7]

The technique was developed at the Broad Institute.[1]

See also[edit]


  1. ^ a b Gallagher, James (2019-10-21). "DNA tool could correct 89% of genetic defects". BBC News. Retrieved 2019-10-22.
  2. ^ Sample, Ian (2019-10-21). "New gene editing tool could fix most harmful DNA mutations". The Guardian. London. ISSN 0261-3077. Retrieved 2019-10-22.
  3. ^ Anzalone, Andrew V.; Randolph, Peyton B.; Davis, Jessie R.; Sousa, Alexander A.; Koblan, Luke W.; Levy, Jonathan M.; Chen, Peter J.; Wilson, Christopher; Newby, Gregory A.; Raguram, Aditya; Liu, David R. (2019-10-21). "Search-and-replace genome editing without double-strand breaks or donor DNA". Nature. doi:10.1038/s41586-019-1711-4. ISSN 1476-4687. PMID 31634902.
  4. ^ Fan, Shelly (2019-11-05). "Everything You Need to Know About Superstar CRISPR Prime Editing". Singularity Hub. Retrieved 2019-11-23.
  5. ^ Cohen, Jon (2019-10-21). "New 'prime' genome editor could surpass CRISPR". Science. AAAS. Retrieved 2019-10-22.
  6. ^ Yasinski, Emma. "New 'Prime Editing' Method Makes Only Single-Stranded DNA Cuts". The Scientist Magazine. Retrieved 2019-10-22.
  7. ^ Lewis, Tanya. "New Gene-Editing Tool Could Fix Genetic Defects—with Fewer Unwanted Effects". Scientific American. Retrieved 2019-10-22.