Proamanullin

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Proamanullin
Proamanullin structure.png
Names
Other names
2-L-Proline-3-isoleucine-alpha-amanitin
Identifiers
3D model (JSmol)
ChemSpider
Properties
C39H54N10O11S
Molar mass 870.97 g/mol
Appearance Colorless, odorless
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in the mushroom genus Amanita.

Toxicology[edit]

Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]

See also[edit]

References[edit]

  1. ^ Cochet-Meilhac M, Chambon P (June 1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta. 353 (2): 160–84. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.

External links[edit]