Procyanidin A2

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Procyanidin A2
Chemical structure of proanthocyanidin A2
IUPAC name
Other names
Dimeric catechin
Procyanidin A2
Procyanidol A2
Proanthocyanidin A-2
Procyanidin dimer A2
(+)-Proanthocyanidin A2
41743-41-3 N
ChEBI CHEBI:28472 YesY
Jmol interactive 3D Image
PubChem 124025
Molar mass 576.51 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Procyanidin A2 is a A type proanthocyanidin.

It can be found in horse chestnut (Aesculus hippocastanum),[1] in cranberry juice concentrate,[2] in peanut[2] skins[3] in Cinchona cinchona and Cinchona pubescens rind, bark and cortex, in Cinnamomum verum (Ceylon cinnamon) rind, bark and cortex, in the fruit of Persea americana (avocado or alligator pear),[4] in Urvillea ulmaceae,[5] and in Ecdysanthera utilis.[6]


Procyanidin B2 can be converted into procyanidin A2 by radical oxidation using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals under neutral conditions.[7]


  1. ^ Facino, R. Maffei; Carini, M.; Brambilla, A.; Bombardelli, E.; Morazzoni, P. (1996). "Proanthocyanidin-A2: a new polyphenol". Cosmetics & Toiletries. 
  2. ^ a b Koerner Jayma, Hsu Victor, Lee Jungmin, Kennedy, James, (2009). "Determination of Proanthocyanidin A2 Content in Phenolic Polymer Isolates by Reversed-Phase High Performance Liquid Chromatography". Journal of Chromatography A 1216 (9): 1403–1409. doi:10.1016/j.chroma.2008.12.086. PMID 19168185. 
  3. ^ Hongxiang Lou; Yamazaku Y.; Sasaku T.; Uchida M.; Tanaka H.; Oka S. (1999). "A-type proanthocyanidins from peanut skins". Phytochemistry 51 (2): 297–308. doi:10.1016/S0031-9422(98)00736-5. 
  4. ^ Proanthocyanidin-A-2 on
  5. ^ Dias, Suziane A.; Cardoso (Gazio), Flávia P.; Santin, Silvana M. O.; Da Costa, Willian F.; Vidotti, Gentil J.; De Souza, Maria Conceição; Sarragiotto, Maria Helena (2009). "Free radical scavenging activity and chemical constituents ofUrvillea ulmaceae". Pharmaceutical Biology 47 (8): 717. doi:10.1080/13880200902933336. 
  6. ^ Lin, Lie-Chwen; Kuo, Yuh-Chi; Chou, Cheng-Jen (2002). "Immunomodulatory Proanthocyanidins fromEcdysantherautilis". Journal of Natural Products 65 (4): 505–8. doi:10.1021/np010414l. PMID 11975489. 
  7. ^ Conversion of procyanidin B-type (catechin dimer) to A-type: evidence for abstraction of C-2 hydrogen in catechin during radical oxidation. Kazunari Kondo, Masaaki Kurihara, Kiyoshi Fukuhara, Takashi Tanaka, Takashi Suzuki, Naoki Miyata and Masatake Toyoda, Tetrahedron Letters, 22 January 2000, Volume 41, Issue 4, Pages 485–488, doi:10.1016/S0040-4039(99)02097-3

Wen LR, Wu D, Jiang YM, Prasad KN, Lin S, Jiang GX, He JR, Zhao MM, Luo W, Yang B. Identification of flavonoids in litchi (Litchi chinensis Sonn.) leaf and evaluation of anticancer activities. Journal of Functional Foods, 2014, 6, 555-563.