Procyclin

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EP1 procyclin
Identifiers
Organism Trypanosoma brucei
Symbol Tb10.6k15.0020
Entrez 3661797
RefSeq (mRNA) XM_818154.1
RefSeq (Prot) XP_823247.1
UniProt Q389V1
Other data
Chromosome 10: 2.48 - 2.48 Mb
Surface protein EP1-2 procyclin
Identifiers
Organism Trypanosoma brucei
Symbol EP1-2
UniProt Q7KG35
EP2 procyclin
Identifiers
Organism Trypanosoma brucei
Symbol Tb10.6k15.0030
Entrez 3661534
RefSeq (mRNA) XM_818153.1
RefSeq (Prot) XP_823246.1
UniProt Q389V2
Other data
Chromosome 10: 2.48 - 2.48 Mb
Surface protein EP2-1 procyclin
Identifiers
Organism Trypanosoma brucei
Symbol EP2-1
UniProt Q95PJ2
Procyclin EP3
Identifiers
Organism Trypanosoma brucei
Symbol EP3
UniProt Q86MA3
EP3-2 procyclin
Identifiers
Organism Trypanosoma brucei
Symbol Tb927.6.520
Entrez 3657688
RefSeq (mRNA) XM_840082.1
RefSeq (Prot) XP_845175.1
UniProt Q581F6
Other data
Chromosome 6: 0.23 - 0.23 Mb
Surface protein EP3-3 procyclin
Identifiers
Organism Trypanosoma brucei
Symbol EP3-3
UniProt Q95NW2
Surface protein EP3-4 procyclin
Identifiers
Organism Trypanosoma brucei
Symbol EP3-4
UniProt Q95PJ3
GPEET2 procyclin precursor
Identifiers
Organism Trypanosoma brucei
Symbol Tb927.6.510, Tb06.28F21.90
Entrez 3657686
RefSeq (mRNA) XM_840081.1
RefSeq (Prot) XP_845174.1
UniProt Q581F9
Other data
Chromosome 6: 0.23 - 0.23 Mb

Procyclins also known as procyclic acidic repetitive proteins or PARP[1] are proteins developed in the surface coating of Trypanosoma brucei parasites while in their tsetse fly vector.[2] The cell surface of the bloodstream form features a dense coat of variable surface glycoproteins (VSGs) which is replaced by an equally dense coat of procyclins when the parasite differentiates into the procylic form in the tsetse fly midgut.

There are six or seven procyclin genes that encode unusual proteins with extensive tandem repeat units of glutamic acid (E) and proline (P), referred to as EP repeats (EP1, EP1-2, EP2, EP2-1, EP3, EP3-2, EP3-4), and two genes that encode proteins with internal pentapeptide GPEET repeats (GPEET2).[3]

EP1 is a 141 amino acids protein and EP2 is a 129 AA protein. Both proteins have their coding genes situated on chromosome 10. GPEET2 is a 114 AA protein and EP3-2 is 123 AA protein with genes situated on chromosome 6.

See also[edit]

References[edit]

  1. ^ Rudenko G, Le Blancq S, Smith J, Lee MG, Rattray A, Van der Ploeg LH (July 1990). "Procyclic acidic repetitive protein (PARP) genes located in an unusually small alpha-amanitin-resistant transcription unit: PARP promoter activity assayed by transient DNA transfection of Trypanosoma brucei". Mol. Cell. Biol. 10 (7): 3492–504. doi:10.1128/MCB.10.7.3492. PMC 360784Freely accessible. PMID 1694012. 
  2. ^ Acosta-Serrano A, Vassella E, Liniger M, Kunz Renggli C, Brun R, Roditi I, Englund PT (February 2001). "The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1513–8. doi:10.1073/pnas.041611698. PMC 29288Freely accessible. PMID 11171982. 
  3. ^ Bütikofer P, Ruepp S, Boschung M, Roditi I (September 1997). "'GPEET' procyclin is the major surface protein of procyclic culture forms of Trypanosoma brucei brucei strain 427". Biochem. J. 326 ( Pt 2): 415–23. PMC 1218686Freely accessible. PMID 9291113. 

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