Proflavine

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Proflavine
Proflavine structure.png
Names
IUPAC name
acridine-3,6-diamine
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.001.976
KEGG
UNII
Properties
C13H11N3
Molar mass 209.252 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Proflavine, also called proflavin and diaminoacridine and bate na bina, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. It has been used in the form of the dihydrochloride and hemisulfate salts as a topical antiseptic, and was formerly used as a urinary antiseptic.

Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acid base pairs. It differs from most other mutagenic components by causing basepair-deletions or basepair-insertions and not substitutions. In the presence of light, proflavine can induce double-stranded breaks in DNA.[1]

Proflavine absorbs strongly in the blue region at 445 nm (in water at pH 7) with molar extinction coefficient of c. 40,000.[2]

References[edit]

  1. ^ Gatasheh, Mansour K; Kannan, S; Hemalatha, K; Imrana, N (2017). "Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen". Karbala International Journal of Modern Science. 3 (4): 272–278. doi:10.1016/j.kijoms.2017.07.003.
  2. ^ Sarre, Peter J. (2006). "The Diffuse Interstellar Bands: A Major Problem in Astronomical Spectroscopy". Journal of Molecular Spectroscopy. 238: 1–10. arXiv:astro-ph/0608113. Bibcode:2006JMoSp.238....1S. doi:10.1016/j.jms.2006.03.009.