Proglumetacin

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Proglumetacin
Proglumetacin.svg
Clinical data
Synonyms3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
MetabolismHepatic. Undergoes enterohepatic recirculation
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
Chemical and physical data
FormulaC46H58ClN5O8
Molar mass844.43442 g/mol
3D model (JSmol)
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Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a nonsteroidal anti-inflammatory drug (NSAID). It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.

References[edit]

  1. ^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung. 37 (6): 698–702. PMID 3663267.