Progress M-48 was launched by a Soyuz-U carrier rocket from Site 1/5 at the Baikonur Cosmodrome. Launch occurred at 01:47:59 GMT on 29 August 2003. The spacecraft docked with the Aft port of the Zvezda module at 03:40:45 GMT on 31 August. It remained docked for five months before undocking at 08:35:56 GMT on 28 January 2004 to make way for Progress M1-11. It was deorbited at 13:11 GMT on the same day. The spacecraft burned up in the atmosphere over the Pacific Ocean, with any remaining debris landing in the ocean at around 13:57:12 GMT.
Progress M-48 carried supplies to the International Space Station, including food, water and oxygen for the crew and equipment for conducting scientific research.
Payloads are separated by bullets ( · ), launches by pipes ( | ). Manned flights are indicated in bold text. Uncatalogued launch failures are listed in italics. Payloads deployed from other spacecraft are denoted in brackets.