Progress M-61 was launched by a Soyuz-U carrier rocket from Site 1/5 at the Baikonur Cosmodrome. Launch occurred at 17:33:47 GMT on 2 August 2007. The spacecraft docked with the Pirs module at 18:40 GMT on 5 August. It remained docked for almost five months before undocking at 03:59 GMT on 22 December 2007. Following undocking it conducted technological experiments and research as part of the Plazma-Progress programme for a month prior to being deorbited. It was deorbited at 19:06 GMT on 22 January 2008. The spacecraft burned up in the atmosphere over the Pacific Ocean, with any remaining debris landing in the ocean at around 19:51 GMT.
Progress M-61 carried supplies to the International Space Station, including food, water and oxygen for the crew and equipment for conducting scientific research.
Payloads are separated by bullets ( · ), launches by pipes ( | ). Manned flights are indicated in bold text. Uncatalogued launch failures are listed in italics. Payloads deployed from other spacecraft are denoted in brackets.