Progress M-63 was launched by a Soyuz-U carrier rocket from Site 1/5 at the Baikonur Cosmodrome. Launch occurred at 13:02 GMT on 5 February 2008. The spacecraft docked with the Pirs module at 14:38 GMT on 7 February. Pirs had been vacated by the departure of Progress M-62 which had undocked on 4 February. Progress M-63 successfully docked using the automated Kurs system, however cosmonaut Yuri Malenchenko was standing by to guide it in using the backup manual TORU system should it have been necessary. Progress M-63 remained docked for two months before undocking at 08:49 GMT on 7 April 2008. It was deorbited at 11:50 GMT on 7 April 2008. The spacecraft burned up in the atmosphere over the Pacific Ocean, with any remaining debris landing in the ocean at around 12:36 GMT.
Progress M-63 carried supplies to the International Space Station, including food, water and oxygen for the crew and equipment for conducting scientific research. Its cargo consisted of over 528.5 kilograms (1,165 lb) of propellant, 46 kilograms (101 lb) of oxygen and air, approximately 419.5 kilograms (925 lb) of water and 1,326.6 kilograms (2,925 lb) of dry cargo. The total mass of its cargo was 2,326 kilograms (5,128 lb).
Payloads are separated by bullets ( · ), launches by pipes ( | ). Manned flights are indicated in bold text. Uncatalogued launch failures are listed in italics. Payloads deployed from other spacecraft are denoted in brackets.