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Prokineticin 1
Prokineticin 1[1]
Symbol PROK1
Entrez 84432
HUGO 18454
OMIM 606233
RefSeq NM_032414
UniProt P58294
Other data
Locus Chr. 1 p21
prokineticin 2
Symbol PROK2
Entrez 60675
HUGO 18455
OMIM 607002
RefSeq NM_021935
UniProt Q9HC23
Other data
Locus Chr. 3 p21.1

Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle.[2]

Recently, prokineticins have been recognized in humans and other vertebrates.[3] They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception.[3] Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle.[4]

Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[5]

See also[edit]


  1. ^ "RCSB Protein Data Bank - Structure Summary for 2KRA - Solution structure of Bv8". 
  2. ^ Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY (2001). "Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle". Mol. Pharmacol. 59 (4): 692–8. PMID 11259612. 
  3. ^ a b Morales RA, Daly NL, Vetter I, et al. (September 2010). "Chemical synthesis and structure of the prokineticin Bv8". Chembiochem. 11 (13): 1882–8. PMID 20677202. doi:10.1002/cbic.201000330. 
  4. ^ Negri L, Lattanzi R, Giannini E, Melchiorri P (September 2007). "Bv8/Prokineticin proteins and their receptors". Life Sci. 81 (14): 1103–16. PMID 17881008. doi:10.1016/j.lfs.2007.08.011. 
  5. ^ Narula, Harmeet S.; Carlson, Harold E. (2014). "Gynaecomastia—pathophysiology, diagnosis and treatment". Nature Reviews Endocrinology. 10 (11): 684–698. ISSN 1759-5029. PMID 25112235. doi:10.1038/nrendo.2014.139. 

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