Prokineticin receptor 2

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Aliases PROKR2, GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3, prokineticin receptor 2
External IDs MGI: 2181363 HomoloGene: 16368 GeneCards: PROKR2
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PROKR2
Genomic location for PROKR2
Band 20p12.3 Start 5,302,040 bp[1]
End 5,314,369 bp[1]
RNA expression pattern
PBB GE PROKR2 gnf1h10315 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 5.3 – 5.31 Mb Chr 20: 132.34 – 132.39 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Prokineticin receptor 2 (PKR2), is a G protein-coupled receptor encoded by the PROKR2 gene in humans.[5]


Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[5]

Mutations in the PROKR2 (also known as KAL3) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[6]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101292 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050558 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: PROKR2 prokineticin receptor 2". 
  6. ^ Narula HS, Carlson HE (November 2014). "Gynaecomastia--pathophysiology, diagnosis and treatment". Nature Reviews. Endocrinology. 10 (11): 684–98. PMID 25112235. doi:10.1038/nrendo.2014.139. 

Further reading[edit]

  • Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY (May 2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". The Journal of Biological Chemistry. 277 (22): 19276–80. PMID 11886876. doi:10.1074/jbc.M202139200. 
  • Soga T, Matsumoto Si, Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K (December 2002). "Molecular cloning and characterization of prokineticin receptors". Biochimica et Biophysica Acta. 1579 (2-3): 173–9. PMID 12427552. doi:10.1016/S0167-4781(02)00546-8. 
  • Battersby S, Critchley HO, Morgan K, Millar RP, Jabbour HN (May 2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". The Journal of Clinical Endocrinology and Metabolism. 89 (5): 2463–9. PMID 15126578. doi:10.1210/jc.2003-032012. 
  • Pasquali D, Rossi V, Staibano S, De Rosa G, Chieffi P, Prezioso D, Mirone V, Mascolo M, Tramontano D, Bellastella A, Sinisi AA (September 2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology. 147 (9): 4245–51. PMID 16763065. doi:10.1210/en.2006-0614. 
  • Dodé C, Teixeira L, Levilliers J, Fouveaut C, Bouchard P, Kottler ML, Lespinasse J, Lienhardt-Roussie A, Mathieu M, Moerman A, Morgan G, Murat A, Toublanc JE, Wolczynski S, Delpech M, Petit C, Young J, Hardelin JP (October 2006). "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2". PLoS Genetics. 2 (10): e175. PMC 1617130Freely accessible. PMID 17054399. doi:10.1371/journal.pgen.0020175. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.