Proline—tRNA ligase

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proline—tRNA ligase
EC number6.1.1.15
CAS number9055-68-9
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a proline—tRNA ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + L-proline + tRNAPro AMP + diphosphate + L-prolyl-tRNAPro

The 3 substrates of this enzyme are ATP, L-proline, and tRNA(Pro), whereas its 3 products are AMP, diphosphate, and L-prolyl-tRNA(Pro).

This enzyme participates in arginine and proline metabolism and aminoacyl-trna biosynthesis.


This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-proline:tRNAPro ligase (AMP-forming). Other names in common use include prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, and prolinyl-tRNA ligase.


Further reading[edit]

  • Norton SJ (July 1964). "PURIFICATION AND PROPERTIES OF THE PROLYL RNA SYNTHETASE OF ESCHERICHIA COLI". Archives of Biochemistry and Biophysics. 106: 147–52. doi:10.1016/0003-9861(64)90167-5. PMID 14217147.
  • Peterson PJ, Fowden L (October 1965). "Purification, properties and comparative specificities of the enzyme prolyl-transfer ribonucleic acid synthetase from Phaseolus aureus and Polygonatum multiflorum". The Biochemical Journal. 97 (1): 112–24. PMC 1264550. PMID 16749091.