Pronethalol

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Pronethalol
Pronethalol.svg
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • Withdrawn
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard 100.237.125 Edit this at Wikidata
Chemical and physical data
Formula C15H19NO
Molar mass 229.32 g/mol
3D model (JSmol)
Chirality Racemic mixture

Pronethalol (Alderlin, Nethalide) was an early non-selective beta blocker clinical candidate. It was never used clinically due to carcinogenicity in mice, which was thought to result from formation of a carcinogenic naphthalene epoxide metabolite.[1]

See also[edit]

References[edit]

  1. ^ Stapleton MP (1997). "Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology". Tex Heart Inst J. 24 (4): 336–42. PMC 325477. PMID 9456487.