Propentofylline

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Propentofylline
Propentofylline.svg
Systematic (IUPAC) name
3-methyl-1-(5-oxohexyl)-7-propyl-3,7-dihydro-1H-purine-2,6-dione
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
CAS Registry Number 55242-55-2 YesY
ATC code N06BC02 QC04AD90
PubChem CID: 4938
UNII 5RTA398U4H YesY
Chemical data
Formula C15H22N4O3
Molecular mass 306.360 g/mol
 YesY (what is this?)  (verify)

Propentofylline (HWA 285) is a xanthine derivative with purported neuroprotective effects.

Pharmacology[edit]

It is a phosphodiesterase inhibitor.[1]

It also acts as an adenosine reuptake inhibitor.[1][2][3]

Uses[edit]

It was studied as a possible treatment for Alzheimer's disease and multi-infarct dementia.[4][5]

Propentofylline has also been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties.[6][7]

Propentofylline is in use in veterinary medicine as a geriatric preparation for old dogs.

See also[edit]

References[edit]

  1. ^ a b Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A, ed. "Propentofylline for dementia". Cochrane Database Syst Rev (2): CD002853. doi:10.1002/14651858.CD002853. PMID 12804440. 
  2. ^ Salimi S; Fotouhi A; Ghoreishi A et al. (April 2008). "A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia". Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (3): 726–732. doi:10.1016/j.pnpbp.2007.11.021. PMID 18096287. 
  3. ^ Numagami Y, Marro PJ, Mishra OP, Delivoria-Papadopoulos M (June 1998). "Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet". Neuroscience 84 (4): 1127–1133. doi:10.1016/S0306-4522(97)00542-3. PMID 9578400. 
  4. ^ Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A, ed. "Propentofylline for dementia". Cochrane database of systematic reviews (Online) (2): CD002853. doi:10.1002/14651858.CD002853. PMID 12804440. 
  5. ^ Kittner B, Rössner M, Rother M (1997). "Clinical trials in dementia with propentofylline". Ann. N. Y. Acad. Sci. 826: 307–316. doi:10.1111/j.1749-6632.1997.tb48481.x. PMID 9329701. 
  6. ^ Bath PM, Bath-Hextall FJ (2004). Bath, Philip MW, ed. "Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke". Cochrane database of systematic reviews (Online) (3): CD000162. doi:10.1002/14651858.CD000162.pub2. PMID 15266424. 
  7. ^ Huber M, Kittner B, Hojer C, Fink GR, Neveling M, Heiss WD (1993). "Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke". J. Cereb. Blood Flow Metab. 13 (3): 526–30. doi:10.1038/jcbfm.1993.68. PMID 8478410.