Propionate—CoA ligase

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propionate-CoA ligase
Identifiers
EC number6.2.1.17
CAS number55326-49-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a propionate-CoA ligase (EC 6.2.1.17) is an enzyme that catalyzes the chemical reaction

ATP + propanoate + CoA AMP + diphosphate + propanoyl-CoA

The 3 substrates of this enzyme are ATP, propanoate, and CoA, whereas its 3 products are AMP, diphosphate, and propanoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is propanoate:CoA ligase (AMP-forming). This enzyme is also called propionyl-CoA synthetase. This enzyme participates in propanoate metabolism.

References[edit]

  • Ricks CA, Cook RM (1981). "Regulation of volatile fatty acid uptake by mitochondrial acyl CoA synthetases of bovine liver". Journal of Dairy Science. 64 (12): 2324–35. doi:10.3168/jds.S0022-0302(81)82854-8. PMID 7341659.