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Not to be confused with Profadol, Propanol, or Propranolol.
Propofol (INN)
Ball-and-stick model of propofol
Systematic (IUPAC) name
Clinical data
AHFS/ monograph
  • AU: C
  • US: B (No risk in non-human studies)
Legal status
Physical: very low (seizures)
Psychological: no data
Routes of
Pharmacokinetic data
Bioavailability NA
Protein binding 95% to 99%
Metabolism Hepatic glucuronidation
Biological half-life 30 to 60 min
Excretion Hepatic
CAS Registry Number 2078-54-8 YesY
ATC code N01AX10
PubChem CID: 4943
DrugBank DB00818 YesY
ChemSpider 4774 YesY
KEGG D00549 YesY
ChEBI CHEBI:44915 YesY
Chemical data
Formula C12H18O
Molecular mass 178.271 g/mol
 YesY (what is this?)  (verify)

Propofol marketed as Diprivan, is a short-acting, intravenously administered hypnotic/amnestic agent. Its uses include the induction and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Propofol is also commonly used in veterinary medicine.

Propofol has largely replaced sodium thiopental for induction of anesthesia because recovery from propofol is more rapid and "clear" when compared with thiopental. Propofol is not a pain medication, so opioids such as fentanyl may be combined with propofol to alleviate pain.[2] Whether or not this is always needed is unclear.[3]

Propofol has been referred to as milk of amnesia (a play on words of milk of magnesia), because of the milk-like appearance of its intravenous preparation.[4] It is on the WHO Model List of Essential Medicines, the most important medications needed in a health system.[5] It is approved for use in more than 50 countries, and generic versions are available.

Medical uses[edit]


Propofol is used for induction and maintenance (in some cases) of anesthesia, having largely replaced sodium thiopental.[2] It can also be administered as part of an anaesthesia maintenance technique called total intravenous anesthesia using either manually-programmed infusion pumps or computer-controlled infusion pumps in a process called target controlled infusion or TCI. Propofol is also used to sedate individuals who are receiving mechanical ventilation but are not undergoing surgery, such as patients in the intensive care unit. In critically ill patients, propofol has been found to be superior to lorazepam both in effectiveness and overall cost.[6]

Procedural sedation[edit]

Propofol is also used for procedural sedation, for example during endoscopic procedures. Its use in these settings results in a faster recovery compared to midazolam.[7] Because of its fast induction and recovery time, propofol is also widely used for sedation of infants and children undergoing MRI.[8] It is also often used in combination with ketamine as the two together have lower rates of side effects.[9]

Other uses[edit]


The Missouri Supreme Court decided to allow the use of propofol to execute prisoners condemned to death. However, the first execution by administration of a lethal dose of propofol was halted on 11 October 2013 by governor Jay Nixon following threats from the European Union to limit the drug's export if it were used for that purpose.[10][11]

Recreational use[edit]

Recreational use of the drug via self-administration has been reported[12][13] (including among medical professionals, see below), but is relatively rare due to its potency and the level of monitoring required for safe use.[citation needed] Critically, the steep dose-response curve of the drug makes potential misuse very dangerous without proper monitoring, and deaths from self-administration continue to be reported.[14][15]

The short-term effects sought via recreational use include mild euphoria, hallucinations, and disinhibition.[16][17] The euphoria caused by propofol has been reported to be unlike that caused by other sedation agents; as one anesthetist reported, "I... remember my first experience using [administering] propofol: a young woman... emerging from a MAC anesthesia looked at me as though I were a masked Brad Pitt and told me that she felt simply wonderful."[18]

Recreational use of the drug has been described amongst medical staff, such as anesthetists who have access to the drug,[19] and is reportedly more common among anesthetists on rotations with short rest periods (as rousing is to a well-rested state).[20] Long-term use has been reported to result in addiction.[19][21]

Attention to the risks of off-label use of propofol increased in August 2009 due to the Los Angeles County coroner's conclusion that music icon Michael Jackson died from a mixture of propofol and the benzodiazepine drugs lorazepam and diazepam.[22][23][24][25] According to a 22 July 2009 search warrant affidavit unsealed by the district court of Harris County, Texas, Jackson's personal physician, Conrad Murray, administered 25 milligrams of propofol diluted with lidocaine shortly before Jackson's death.[23][24][26][better source needed] Even so, as of 2009 propofol was not on a U.S Drug Enforcement Administration schedule.[20][27]

Side effects[edit]

One of propofol's most frequent side effects is pain on injection, especially in smaller veins. This pain arises from activation of the pain receptor, TRPA1,[28] found on sensory nerves and can be mitigated by pretreatment with lidocaine.[29] Less pain is experienced when infused at a slower rate in a large vein (antecubital fossa). Patients show great variability in their response to propofol, at times showing profound sedation with small doses.

Additional side effects include low blood pressure related to vasodilation, transient apnea following induction doses, and cerebrovascular effects. Propofol has more pronounced hemodynamic effects relative to many intravenous anesthetic agents.[30] Reports of blood pressure drops of 30% or more are thought to be at least partially due to inhibition of sympathetic nerve activity.[31] This effect is related to dose and rate of propofol administration. It may also be potentiated by opioid analgesics.[32] Propofol can also cause decreased systemic vascular resistance, myocardial blood flow, and oxygen consumption, possibly through direct vasodilation.[33]

As a respiratory depressant, propofol frequently produces apnea. The persistence of apnea can depend on factors such as premedication, dose administered, and rate of administration, and may sometimes persist for longer than 60 seconds.[34] Possibly as the result of depression of the central inspiratory drive, propofol may produce significant decreases in respiratory rate, minute volume, tidal volume, mean inspiratory flow rate, and functional residual capacity.[30]

Diminishing cerebral blood flow, cerebral metabolic oxygen consumption, and intracranial pressure are also characteristics of propofol administration.[35] In addition, propofol may decrease intraocular pressure by as much as 50% in patients with normal intraocular pressure.[36]

A more serious but rare side effect is dystonia.[37] Mild myoclonic movements are common, as with other intravenous hypnotic agents. Propofol appears to be safe for use in porphyria, and has not been known to trigger malignant hyperpyrexia.[citation needed]

Propofol is also reported to induce priapism in some individuals,[38][39] and has been observed to suppress REM sleep stage and to worsen the poor sleep quality in some patients.[40]

As with any other general anesthetic agent, propofol should be administered only where appropriately trained staff and facilities for monitoring are available, as well as proper airway management, a supply of supplemental oxygen, artificial ventilation, and cardiovascular resuscitation.[41]

Propofol infusion syndrome[edit]

Another recently described rare, but serious, side effect is propofol infusion syndrome. This potentially lethal metabolic derangement has been reported in critically ill patients after a prolonged infusion of high-dose substance in combination with catecholamines and/or corticosteroids.[42]

CBS genetic defects[edit]

People with this gene have trouble processing sulphites (one of the potential ingredients), and should discuss use of this drug with their specialist.


The respiratory effects of propofol are increased if give with other respiratory depressants, including benzodiazepines.[43]

Mechanism of action[edit]

Propofol has been proposed to have several mechanisms of action,[44][45][46] both through potentiation of GABAA receptor activity, thereby slowing the channel-closing time,[47][48][49] and also acting as a sodium channel blocker.[50][51] Recent research has also suggested that the endocannabinoid system may contribute significantly to propofol's anesthetic action and to its unique properties.[52] EEG research upon those undergoing general anesthesia with propofol finds that it causes a prominent reduction in the brain's information integration capacity at gamma wave band frequencies.[53]

Researchers have identified the site where propofol binds to GABAA receptors in the brain, on the second transmembrane domain of the beta subunit of the GABA A receptor.[54]


Propofol is highly protein-bound in vivo and is metabolised by conjugation in the liver.[55] The half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of propofol typically wears off within minutes. Propofol is versatile; the drug can be given for short or prolonged sedation, as well as for general anesthesia. Its use is not associated with nausea as is often seen with opioid medications. These characteristics of rapid onset and recovery along with its amnestic effects[56] have led to its widespread use for sedation and anesthesia.


Large vial filled with milky white fluid
A 20-ml ampoule of 1% propofol emulsion, as sold in Australia by Sandoz

Propofol was originally developed in the UK by Imperial Chemical Industries as ICI 35868. Clinical trials followed in 1977, using a form solubilised in cremophor EL. However, due to anaphylactic reactions to cremophor, this formulation was withdrawn from the market and subsequently reformulated as an emulsion of a soya oil/propofol mixture in water. The emulsified formulation was relaunched in 1986 by ICI (now AstraZeneca) under the brand name Diprivan. The currently available preparation is 1% propofol, 10% soybean oil, and 1.2% purified egg phospholipid as an emulsifier, with 2.25% glycerol as a tonicity-adjusting agent, and sodium hydroxide to adjust the pH. Diprivan contains EDTA, a common chelation agent, that also acts alone (bacteriostatically against some bacteria) and synergistically with some other antimicrobial agents. Newer generic formulations contain sodium metabisulfite or benzyl alcohol as antimicrobial agents. Propofol emulsion is a highly opaque white fluid due to the scattering of light from the tiny (about 150-nm) oil droplets it contains.

A water-soluble prodrug form, fospropofol, has recently been developed and tested with positive results. Fospropofol is rapidly broken down by the enzyme alkaline phosphatase to form propofol. Marketed as Lusedra, this new formulation may not produce the pain at injection site that often occurs with the traditional form of the drug. The US Food and Drug Administration approved the product in 2008.[57] However fospropofol is a controlled substance unlike propofol.

Society and culture[edit]

Supply issues[edit]

On 4 June 2010, Teva Pharmaceutical Industries Ltd., an Israel-based pharmaceutical firm and a major supplier of the drug, announced the firm would no longer manufacture it. This aggravates an already existing shortage, caused by manufacturing difficulties at Teva and Hospira. A Teva spokesperson attributed the halt to ongoing process difficulties, and a number of pending lawsuits related to the drug.[58] In Switzerland, various preparations of the drug are supplied by Fresenius-Kabi, a German company.

Recent developments[edit]

By incorporation of an azobenzene unit, a photoswitchable version of propofol (AP2) was developed in 2012 that allows for optical control of GABAA receptors with light.[59] In 2013, a propofol binding site on mammalian GABAA receptors has been identified by photolabeling using a Diazirine derivative.[60] Additionally, it was shown that the hyaluronan polymer present in the synovia can be protected from free-radical depolymerization by propofol.[61]


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