Prostaglandin F receptor

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Aliases PTGFR, FP, Prostaglandin F receptor
External IDs MGI: 97796 HomoloGene: 741 GeneCards: PTGFR
Targeted by Drug
tafluprost, bimatoprost, latanoprost, prostaglandin D2, dinoprostone, dinoprost, sulprostone, U46619[1]
RNA expression pattern
PBB GE PTGFR 207177 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 78.3 – 78.54 Mb Chr 3: 151.8 – 151.84 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F. It is encoded by the gene PTGFR.[4]

It is a member of the G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG.

Two transcript variants encoding different isoforms have been found for this gene.[4]


Main effects of prostaglandin binding to the receptor are:

Via activation of this receptor, PGF2-alpha mediates luteolysis,[4] and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.[6]

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[7]

See also[edit]


  1. ^ "Drugs that physically interact with Prostaglandin F2-alpha receptor view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b c "Entrez Gene: PTGFR prostaglandin F receptor (FP)". 
  5. ^ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003) Page 234
  6. ^ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
  7. ^ Sugimoto Y, Yamasaki A, Segi E, et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science. 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889. 

External links[edit]

  • "Prostanoid Receptors: FP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.