Prostaglandin H2

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Prostaglandin H2
Prostaglandin H2 skeletal.svg
Names
Other names
PGH2, Endoperoxide H2, Prostaglandin R2
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
MeSH Prostaglandin+H2
Properties
C20H32O5
Molar mass 352.465 g/mol
Density 1.129 ± 40.0 g/mL
Boiling point 490 ± 40.0 °C
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Prostaglandin H2 is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme.[1]

Eicosanoid synthesis - prostaglandin H2 near center

It is acted upon by:

It rearranges non-enzymatically to:

Use of Prostaglandin H2:

  • regulating the constriction and dilation of blood vessels
  • stimulating platelet aggregation

Effects of Aspirin on Prostaglandin H2:

  • Aspirin has been hypothesized to block the conversion of arachidonic acid to Prostaglandin
Figure 1: Synthetic pathways from PGH2 (the parent compound) to prostaglandins, prostacyclin and thromboxanes

References[edit]

  1. ^ Van Der Donk, Wilfred A.; Tsai, Ah-Lim; Kulmacz, Richard J. (2002). "The Cyclooxygenase Reaction Mechanism". Biochemistry. 41 (52): 15451–15458. doi:10.1021/bi026938h.

2. "Prostaglandin H2". SciFinder. Retrieved 22 October 2017.

3. "Acetylation of Prostaglandin H2 Synthases by Aspirin is Inhibited by Redox Cycling of the Peroxidase". "Biochem Pharmacol. Retrieved 22 October 2017.