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Skeletal formula of prosultiamine
Ball-and-stick model of the prosultiamine molecule
Clinical data
AHFS/ International Drug Names
Routes of
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
CAS Number
PubChem CID
ECHA InfoCard 100.000.397
Chemical and physical data
Formula C15H24N4O2S2
Molar mass 356.51 g/mol
3D model (JSmol)

Prosultiamine (Alinamin, Binova, Jubedel, Taketron, Thiobeta, Thiotiamina), also known as thiamine propyl disulfide (TPD), is a disulfide thiamine derivative developed in Japan in the 1950s as a treatment for vitamin B1 deficiency.[1][2] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.[3][4] It is also a potential treatment for HTLV, since it has been shown to reduce viral load and symptoms.[5]

See also[edit]


  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. 
  2. ^ David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9. 
  3. ^ Thomson AD, Frank O, Baker H, Leevy CM (April 1971). "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine. 74 (4): 529–34. PMID 5551161. doi:10.7326/0003-4819-74-4-529. 
  4. ^ Baker H, Frank O (August 1976). "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology. 22 SUPPL: 63–8. PMID 978282. 
  5. ^ Nervous System Disease: A New Outlet for an Old Drug?