Silver proteinate (brand name: Protargol) is used in electron microscopy with periodic acid and thiocarbohydrazide or thiosemicarbohydrazide as a positive stain for carbohydrates such as glycogen. It can also be used for light microscopy to stain nerve tissue. It is normally available as 8% silver in combination with albumin.
Because of its bactericidal properties it was used to treat gonorrhea before the discovery of antibiotics. Designer of first silver protein formulation was Arthur Eichengrün, German chemist working for Bayer. It was introduced for therapeutic use in 1897.
- Silver proteinate at Sigma-Aldrich
- Vaupel, E. (2005), Arthur Eichengrün—Tribute to a Forgotten Chemist, Entrepreneur, and German Jew Angew. Chem. Int. Ed., 44: 3344–3355. doi: 10.1002/anie.200462959
- State Medical Examining and Licensing Boards A Handbook of Useful Drugs: Protargol 1913 Press Of The American Medical Association (hosted on: chestofbooks.com)