Protein-glutamine gamma-glutamyltransferase

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protein-glutamine gamma-glutamyltransferase
EC number
CAS number 80146-85-6
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a protein-glutamine gamma-glutamyltransferase (EC is an enzyme that catalyzes the chemical reaction

protein glutamine + alkylamine protein N5-alkylglutamine + NH3

Thus, the two substrates of this enzyme are protein glutamine and alkylamine, whereas its two products are protein N(5)-alkylglutamine and NH3.

This enzyme participates in complement and coagulation cascades and Huntington's disease. It employs one cofactor, calcium.


This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is protein-glutamine:amine gamma-glutamyltransferase. Other names in common use include:

  • factor XIIIa,
  • fibrin stabilizing factor,
  • fibrinoligase,
  • glutaminylpeptide gamma-glutamyltransferase,
  • polyamine transglutaminase,
  • R-glutaminyl-peptide:amine gamma-glutamyl transferase
  • tissue transglutaminase, and
  • transglutaminase.

Structural studies[edit]

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1EVU, 1EX0, 1F13, 1FIE, 1G0D, 1GGT, 1GGU, 1GGY, 1IU4, 1KV3, 1L9M, 1L9N, 1NUD, 1NUF, 1NUG, 1QRK, 1RLE, 1SGX, and 1VJJ.


* Folk JE, Chung SI (1973). "Molecular and catalytic properties of transglutaminases". Adv. Enzymol. Relat. Areas Mol. Biol. Advances in Enzymology - and Related Areas of Molecular Biology. 38: 109–91. doi:10.1002/9780470122839.ch3. ISBN 978-0-470-12283-9. PMID 4151471.