Protein losing enteropathy

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Protein-losing enteropathy
Classification and external resources
ICD-10 K90.4
ICD-9-CM 579.8
OMIM 226300
DiseasesDB 10811
MedlinePlus 002277
eMedicine med/1926 ped/1909
MeSH D011504

Protein-losing enteropathy refers to any condition of the gastrointestinal tract that results in a net loss of protein from the body.[1]

Signs and symptoms[edit]

The condition may manifest itself with complications related to protein loss, including edema, or retention of fluid, and ascites, or retention of fluid in the abdomen. Proteins are absorbed in the small intestine, and any condition that affects the digestion or absorption of protein can result in protein-losing enteropathy.


Causes of protein-losing enteropathy include celiac disease, Crohn's disease, short bowel syndrome (where the absorptive area for proteins is decreased), intestinal lymphangiectasia, amyloidosis, enteropathy caused by NSAIDs, Ménétrier's disease, dyskeratosis congenita, IPEX, and giardiasis.



The diagnosis of protein-losing enteropathy is typically made by excluding other causes of protein loss, such as nephrotic syndrome. Endoscopy and barium imaging can be used to localize the cause of the protein loss in the bowel. Faecal excretion of alpha 1-antitrypsin is a marker of protein-losing enteropathy.


Treatment depends upon the underlying condition.


  1. ^ "Protein-losing enteropathy: MedlinePlus Medical Encyclopedia". Retrieved 2015-12-16.