GLUD2

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GLUD2
PDB 1hwx EBI.jpg
Identifiers
Aliases GLUD2, GDH2, GLUDP1, glutamate dehydrogenase 2
External IDs HomoloGene: 115647 GeneCards: GLUD2
Gene location (Human)
X chromosome (human)
Chr. X chromosome (human)[1]
X chromosome (human)
Genomic location for GLUD2
Genomic location for GLUD2
Band No data available Start 121,047,588 bp[1]
End 121,050,080 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012084

n/a

RefSeq (protein)

NP_036216

n/a

Location (UCSC) Chr X: 121.05 – 121.05 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Glutamate dehydrogenase 2, mitochondrial, also known as GDH 2, is an enzyme that in humans is encoded by the GLUD2 gene.[3][4][5] This dehydrogenase is one of the family of glutamate dehydrogenases that are ubiquitous in life.

Function[edit]

Glutamate dehydrogenase 2 is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate.[3]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182890 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ a b "Entrez Gene: glutamate dehydrogenase 2". 
  4. ^ Shashidharan P, Michaelidis TM, Robakis NK, Kresovali A, Papamatheakis J, Plaitakis A (June 1994). "Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene". J. Biol. Chem. 269 (24): 16971–6. PMID 8207021. 
  5. ^ Shashidharan P, Clarke DD, Ahmed N, Moschonas N, Plaitakis A (May 1997). "Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP". J. Neurochem. 68 (5): 1804–11. PMID 9109504. doi:10.1046/j.1471-4159.1997.68051804.x. 

Further reading[edit]