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Glutamate dehydrogenase 2
PDB 1hwx EBI.jpg
PDB rendering based on 1hwx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GLUD2 ; GDH2; GLUDP1
External IDs OMIM300144 HomoloGene115647 GeneCards: GLUD2 Gene
EC number
Species Human Mouse
Entrez 2747 n/a
Ensembl ENSG00000182890 n/a
UniProt P49448 n/a
RefSeq (mRNA) NM_012084 n/a
RefSeq (protein) NP_036216 n/a
Location (UCSC) Chr X:
121.05 – 121.05 Mb
PubMed search [1] n/a

Glutamate dehydrogenase 2, mitochondrial, also known as GDH 2, is an enzyme that in humans is encoded by the GLUD2 gene.[1][2][3]


Glutamate dehydrogenase 2 is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate.[1]


  1. ^ a b "Entrez Gene: glutamate dehydrogenase 2". 
  2. ^ Shashidharan P, Michaelidis TM, Robakis NK, Kresovali A, Papamatheakis J, Plaitakis A (June 1994). "Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene". J. Biol. Chem. 269 (24): 16971–6. PMID 8207021. 
  3. ^ Shashidharan P, Clarke DD, Ahmed N, Moschonas N, Plaitakis A (May 1997). "Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP". J. Neurochem. 68 (5): 1804–11. doi:10.1046/j.1471-4159.1997.68051804.x. PMID 9109504. 

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