Protein SET

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SET nuclear proto-oncogene
Protein SET PDB 2e50.png
PDB rendering based on 2e50.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600960 MGI1860267 HomoloGene55707 GeneCards: SET Gene
Species Human Mouse
Entrez 6418 56086
Ensembl ENSG00000119335 ENSMUSG00000054766
UniProt Q01105 Q9EQU5
RefSeq (mRNA) NM_001122821 NM_001204875
RefSeq (protein) NP_001116293 NP_001191804
Location (UCSC) Chr 9:
128.68 – 128.7 Mb
Chr 2:
30.06 – 30.07 Mb
PubMed search [1] [2]

Protein SET is a protein that in humans is encoded by the SET gene.[1][2][3]


Protein SET has been shown to interact with:


  1. ^ von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Molecular and Cellular Biology 12 (8): 3346–55. PMC 364582. PMID 1630450. 
  2. ^ Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". The Journal of Biological Chemistry 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647. 
  3. ^ "Entrez Gene: SET SET translocation (myeloid leukemia-associated)". 
  4. ^ a b Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell 104 (1): 119–30. PMID 11163245. 
  5. ^ Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology 22 (8): 2810–20. PMC 133744. PMID 11909973. 
  6. ^ Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927. 
  7. ^ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology 23 (23): 8528–41. PMC 262669. PMID 14612398. 
  8. ^ Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell 112 (5): 659–72. PMID 12628186. 

Further reading[edit]