Protein kinase, AMP-activated, alpha 1

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Protein kinase, AMP-activated, alpha 1 catalytic subunit
Protein PRKAA1 PDB 2h6d.png
PDB rendering based on 2h6d.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRKAA1 ; AMPK; AMPKa1
External IDs OMIM602739 MGI2145955 HomoloGene49590 ChEMBL: 4045 GeneCards: PRKAA1 Gene
EC number,,,
RNA expression pattern
PBB GE PRKAA1 209799 at tn.png
More reference expression data
Species Human Mouse
Entrez 5562 105787
Ensembl ENSG00000132356 ENSMUSG00000050697
UniProt Q13131 Q5EG47
RefSeq (mRNA) NM_006251 NM_001013367
RefSeq (protein) NP_006242 NP_001013385
Location (UCSC) Chr 5:
40.76 – 40.8 Mb
Chr 15:
5.14 – 5.18 Mb
PubMed search [1] [2]

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.[1][2]

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[2]


Protein kinase, AMP-activated, alpha 1 has been shown to interact with TSC2.[3][4]


  1. ^ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660. 
  2. ^ a b "Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit". 
  3. ^ Inoki, Ken; Zhu Tianqing; Guan Kun-Liang (Nov 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell (United States) 115 (5): 577–90. doi:10.1016/S0092-8674(03)00929-2. ISSN 0092-8674. PMID 14651849. 
  4. ^ Shaw, Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell (United States) 6 (1): 91–9. doi:10.1016/j.ccr.2004.06.007. ISSN 1535-6108. PMID 15261145. 

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