Protein kinase D1

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Protein kinase D1
External IDs OMIM605435 MGI99879 HomoloGene55680 ChEMBL: 3863 GeneCards: PRKD1 Gene
EC number
RNA expression pattern
PBB GE PRKD1 205880 at tn.png
More reference expression data
Species Human Mouse
Entrez 5587 18760
Ensembl ENSG00000184304 ENSMUSG00000002688
UniProt Q15139 Q62101
RefSeq (mRNA) NM_002742 NM_008858
RefSeq (protein) NP_002733 NP_032884
Location (UCSC) Chr 14:
29.58 – 30.19 Mb
Chr 12:
50.34 – 50.65 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.[1][2][3]


Members of the protein kinase D (PKD) family function in many extracellular receptor-mediated signal transduction pathways. The PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.[supplied by OMIM][3]


Protein kinase D1 has been shown to interact with:


  1. ^ Johannes FJ, Prestle J, Eis S, Oberhagemann P, Pfizenmaier K (April 1994). "PKCu is a novel, atypical member of the protein kinase C family". J Biol Chem 269 (8): 6140–8. PMID 8119958. 
  2. ^ Owczarek CM, Portbury KJ, Kola I, Hertzog PJ (September 2000). "Assignment of protein kinase C mu (PRKCM) to human chromosome band 14q11 with somatic cell hybrids and radiation hybrids". Cytogenet Cell Genet 89 (3–4): 240–1. doi:10.1159/000015624. PMID 10965134. 
  3. ^ a b "Entrez Gene: PRKD1 protein kinase D1". 
  4. ^ Johannes FJ, Hausser A, Storz P, Truckenmüller L, Link G, Kawakami T, Pfizenmaier K (November 1999). "Bruton's tyrosine kinase (Btk) associates with protein kinase C mu". FEBS Lett. 461 (1-2): 68–72. doi:10.1016/s0014-5793(99)01424-6. PMID 10561498. 
  5. ^ a b Storz P, Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K, Johannes FJ (August 2000). "Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32". J. Biol. Chem. 275 (32): 24601–7. doi:10.1074/jbc.M002964200. PMID 10831594. 
  6. ^ Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A (August 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochem. Biophys. Res. Commun. 307 (3): 459–65. doi:10.1016/s0006-291x(03)01187-2. PMID 12893243. 
  7. ^ Rao PS, Jaggi M, Smith DJ, Hemstreet GP, Balaji KC (October 2003). "Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer". Biochem. Biophys. Res. Commun. 310 (3): 1032–8. doi:10.1016/j.bbrc.2003.09.118. PMID 14550308. 
  8. ^ Hausser A, Storz P, Link G, Stoll H, Liu YC, Altman A, Pfizenmaier K, Johannes FJ (April 1999). "Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins". J. Biol. Chem. 274 (14): 9258–64. doi:10.1074/jbc.274.14.9258. PMID 10092600. 

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