Proteinase 3

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PRTN3
PBB Protein PRTN3 image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRTN3, ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3
External IDs OMIM: 177020 MGI: 893580 HomoloGene: 120934 GeneCards: 5657
RNA expression pattern
PBB GE PRTN3 207341 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002777

NM_011178

RefSeq (protein)

NP_002768.3

NP_035308.2

Location (UCSC) Chr 19: 0.84 – 0.85 Mb Chr 10: 79.87 – 79.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene.[3]

Function[edit]

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis (formerly known as "Wegener's granulomatosis").[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay JE (December 1990). "Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils". J. Exp. Med. 172 (6): 1709–15. doi:10.1084/jem.172.6.1709. PMC 2188764free to read. PMID 2258701. 
  4. ^ van der Geld YM, Limburg PC, Kallenberg CG (February 2001). "Proteinase 3, Wegener's autoantigen: from gene to antigen". J. Leukoc. Biol. 69 (2): 177–90. PMID 11272267. 

Further reading[edit]

External links[edit]