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Protium may refer to:

  • Protium, in physics and chemistry means hydrogen-1, the most common isotope of the element hydrogen, with one proton and no neutrons
  • Protium (plant), a genus of chiefly tropical American trees in the family Burseraceae, having fragrant wood
  • Protium (computer language), a universal, symbolic programming language system
  • Protium, a commercial name for pantoprazole, a so-called "proton inhibitor" drug