Psammoma body

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Micrograph of psammoma body in the centre of the field in a meningioma of brain. H&E stain.

A psammoma body is a round collection of calcium, seen microscopically. The term is derived from the Greek word ψάμμος (psámmos), meaning "sand".


Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from (1) the infarction and calcification of papillae tips and (2) calcification of intralymphatic tumor thrombi.[1]

Association with lesions[edit]

Psammoma bodies are commonly seen in certain tumors such as:

Benign lesions[edit]

Micrograph of a psammomatous melanotic schwannoma with a psammoma body, as may be seen in Carney complex. H&E stain.

Psammoma bodies may be seen in:


Psammoma bodies usually have a laminar appearance, are circular, acellular and basophilic.


  1. ^ Johannessen JV, Sobrinho-Simões M (September 1980). "The origin and significance of thyroid psammoma bodies". Lab. Invest. 43 (3): 287–96. PMID 7401638. 
  2. ^ Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011
  3. ^
  4. ^ "Pancreatic Endocrine Tumors: Radiologic-Clinicopathologic Correlation". RadioGraphics. 30: 1445–1464. doi:10.1148/rg.306105523. 
  5. ^ Robbin's Pathology, Eight Ed
  6. ^ Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med. 36 (9): 675–8. PMID 1774734. 
  7. ^ Rapini, Ronald. Practical Dermatopathology. Elsevier Mosby, 2005, p. 10.

External links[edit]