Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from (1) the infarction and calcification of papillae tips and (2) calcification of intralymphatic tumor thrombi.
Association with lesions
Psammoma bodies are commonly seen in certain tumors such as:
- Papillary thyroid carcinoma
- Papillary renal cell carcinoma
- Micropapillary subtype of lung adenocarcinoma
- Ovarian papillary serous cystadenoma and cystadenocarcinoma
- Endometrial adenocarcinomas (Papillary serous carcinoma ~3%-4%)
- Meningiomas, in the central nervous system
- Peritoneal and Pleural Mesothelioma
- Somatostatinoma (pancreas)
- Prolactinoma of the pituitary 
Psammoma bodies may be seen in:
Psammoma bodies usually have a laminar appearance, are circular, acellular and basophilic.
- Johannessen JV, Sobrinho-Simões M (September 1980). "The origin and significance of thyroid psammoma bodies". Lab. Invest. 43 (3): 287–96. PMID 7401638.
- Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011
- "Pancreatic Endocrine Tumors: Radiologic-Clinicopathologic Correlation". RadioGraphics. 30: 1445–1464. doi:10.1148/rg.306105523.
- Robbin's Pathology, Eight Ed
- Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med. 36 (9): 675–8. PMID 1774734.
- Rapini, Ronald. Practical Dermatopathology. Elsevier Mosby, 2005, p. 10.
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