From Wikipedia, the free encyclopedia
Jump to: navigation, search
Classification and external resources
DiseasesDB 7471

Pseudohyperaldosteronism (also pseudoaldosteronism) is a medical condition that mimics hyperaldosteronism.[1] Like hyperaldosteronism, it produces hypertension associated with low plasma renin activity, and metabolic alkalosis associated with hypokalemia. Unlike hyperaldosteronism, it involves aldosterone levels that are normal or low (hypoaldosteronism).


This condition has several known causes, dietary and genetic. Dietary causes include the chronic excessive ingestion of licorice.[2] Licorice inhibits the 11-beta hydroxysteroid dehydrogenase type II (Protein:HSD11B2) enzyme resulting in inappropriate stimulation of the mineralocorticoid receptor by cortisol.

Genetic causes include Liddle's syndrome.[3]


This condition is characterized by hypertension, kaliuresis and reduced plasma renin.

See also[edit]


  1. ^ Armanini D, Calò L, Semplicini A (June 2003). "Pseudohyperaldosteronism: pathogenetic mechanisms". Crit Rev Clin Lab Sci. 40 (3): 295–335. doi:10.1080/713609355. PMID 12892318. 
  2. ^ Sigurjonsdottir HA, Axelson M, Johannsson G, Manhem K, Nyström E, Wallerstedt S (2006). "The liquorice effect on the RAAS differs between the genders". Blood Press. 15 (3): 169–72. doi:10.1080/08037050600593060. PMID 16864159. 
  3. ^ Takeuchi K, Abe K, Sato M, et al. (February 1989). "Plasma aldosterone level in a female case of pseudohyperaldosteronism (Liddle's syndrome)". Endocrinol. Jpn. 36 (1): 167–73. doi:10.1507/endocrj1954.36.167. PMID 2659310.