Psychopathia Sexualis returns to the theme of serial killers, the subject of most of the songs. Every song title bearing the name of serial killer opens with a spoken introduction, detailing the profile of the serial killer. The introductions are spoken in Spanish, except "Edward Paisnel" spoken in Catalan. While the songs continue to utilize the high pitched feedback known in most albums during the Come Organisation era, the album pursues a diverse sound. Example include, the tape manipulation of the introduction in "Edward Paisnel" and the pulsing beats in the opening track "Peter Kürten". Note that the songs "Peter Kürten" and "Boston Strangler" (pseudonym for the serial killer Albert de Salvo) differ from the songs "Dedicated to Peter Kürten" and "Dedicated to Albert de Salvo - Sadist and Mass Slayer" found on their previous albums. "Live Action 4 (Complete)" is, as the title suggests, Whitehouse's fourth live concert.
Psychopathia Sexualis was originally limited to 500 copies on vinyl on the group owned record label Come Organisation. Unlike most of their albums, Psychopathia Sexualis has not been reissued by Susan Lawly because the master tapes have been lost. Though possible to master from vinyl or cassette with the appropriate technology to remove the scratching and cracking sounds, the group worries that the content of the album would be altered given the already noisy nature of the music.