Pulmonary-renal syndrome

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Pulmonary-renal syndrome is a rare medical syndrome involving bleeding in the lungs and kidney damage[1] (glomerulonephritis).[2]


Causes are usually autoimmune.

It is most commonly due to granulomatosis with polyangiitis or Goodpasture's syndrome. Granulomatosis with polyangiitis usually presents with nasopharyngeal involvement as well, whereas Goodpasture's will not.

Other causes include systemic lupus erythematosus and microscopic polyangiitis.[3]


  1. ^ Herman, PG; Balikian JP; Seltzer SE; Ehrie M (June 1978). "The pulmonary-renal syndrome". American Journal of Roentgenology. American Roentgen Ray Society. 130 (6): 1141–1148. PMID 418654. doi:10.2214/ajr.130.6.1141. 
  2. ^ Sugimoto T, Deji N, Kume S, et al. (2007). "Pulmonary-renal syndrome, diffuse pulmonary hemorrhage and glomerulonephritis, associated with Wegener's granulomatosis effectively treated with early plasma exchange therapy". Intern. Med. 46 (1): 49–53. PMID 17202734. doi:10.2169/internalmedicine.46.6070. 
  3. ^ "Pulmonary-Renal Syndrome: Diffuse Alveolar Hemorrhage and Pulmonary-Renal Syndrome: Merck Manual Professional". Retrieved 2010-04-09.