Pulmonary surfactant-associated protein C

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Protein SFTPC PDB 1spf.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases SFTPC, BRICD6, PSP-C, SFTP2, SMDP2, SP-C, surfactant protein C
External IDs MGI: 109517 HomoloGene: 2271 GeneCards: 6440
RNA expression pattern
PBB GE SFTPC 205982 x at tn.png

PBB GE SFTPC 211735 x at tn.png

PBB GE SFTPC 38691 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 8: 22.16 – 22.16 Mb Chr 14: 70.52 – 70.52 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Pulmonary surfactant-associated protein C is a protein that in humans is encoded by the SFTPC gene.[3][4][5]

It is a membrane protein which manufactures surfactant.

Clinical significance[edit]

It is associated with Surfactant metabolism dysfunction type 2.

Humans and animals born lacking SP-C tend to develop progressive interstitial pneumonitis.

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Keller A, Eistetter HR, Voss T, Schafer KP (Aug 1991). "The pulmonary surfactant protein C (SP-C) precursor is a type II transmembrane protein". Biochem J. 277 (Pt 2): 493–9. PMC 1151261free to read. PMID 1859376. 
  4. ^ Johansson H, Nordling K, Weaver TE, Johansson J (Jul 2006). "The Brichos domain-containing C-terminal part of pro-surfactant protein C binds to an unfolded poly-val transmembrane segment". J Biol Chem. 281 (30): 21032–9. doi:10.1074/jbc.M603001200. PMID 16709565. 
  5. ^ "Entrez Gene: SFTPC surfactant, pulmonary-associated protein C". 

Further reading[edit]

External links[edit]