Pulmonary surfactant-associated protein C

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Surfactant protein C
Protein SFTPC PDB 1spf.png
PDB rendering based on 1spf.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM178620 MGI109517 HomoloGene2271 GeneCards: SFTPC Gene
RNA expression pattern
PBB GE SFTPC 38691 s at tn.png
PBB GE SFTPC 205982 x at tn.png
PBB GE SFTPC 211735 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6440 20389
Ensembl ENSG00000168484 ENSMUSG00000022097
UniProt P11686 Q6P8P8
RefSeq (mRNA) NM_001172357 NM_011359
RefSeq (protein) NP_001165828 NP_035489
Location (UCSC) Chr 8:
22.16 – 22.16 Mb
Chr 14:
70.52 – 70.52 Mb
PubMed search [1] [2]

Pulmonary surfactant-associated protein C is a protein that in humans is encoded by the SFTPC gene.[1][2][3]

It is a membrane protein which manufactures surfactant.

Clinical significance[edit]

It is associated with Surfactant metabolism dysfunction type 2.

Humans and animals born lacking SP-C tend to develop progressive interstitial pneumonitis.

See also[edit]


  1. ^ Keller A, Eistetter HR, Voss T, Schafer KP (Aug 1991). "The pulmonary surfactant protein C (SP-C) precursor is a type II transmembrane protein". Biochem J 277 (Pt 2): 493–9. PMC 1151261. PMID 1859376. 
  2. ^ Johansson H, Nordling K, Weaver TE, Johansson J (Jul 2006). "The Brichos domain-containing C-terminal part of pro-surfactant protein C binds to an unfolded poly-val transmembrane segment". J Biol Chem 281 (30): 21032–9. doi:10.1074/jbc.M603001200. PMID 16709565. 
  3. ^ "Entrez Gene: SFTPC surfactant, pulmonary-associated protein C". 

Further reading[edit]

External links[edit]