Pupillary light reflex

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The W-shaped pupil of the cuttlefish dilating when the lights are turned off

The pupillary light reflex (PLR) or photopupillary reflex is a reflex that controls the diameter of the pupil, in response to the intensity (luminance) of light that falls on the retinal ganglion cells of the eye, thereby assisting in adaptation to various levels of lightness/darkness. A greater intensity of light causes the pupil to constrict (miosis/myosis) (allowing less light in), whereas a lower intensity of light causes the pupil to dilate (mydriasis, expansion) (allowing more light in). Thus, the pupillary light reflex regulates the intensity of light entering the eye.[1] Light shone into one eye will cause both pupils to constrict.

Terminology[edit]

"Pupillary reflex" is synonymous with "pupillary response," which may be pupillary constriction or dilation. "Ipsilateral" means on the same side. "Contralateral" means on the opposite side. Pupillary reflex is conceptually linked to the side (left or right) of the reacting pupil, and not to the side from which light stimulation originates. Left pupillary reflex refers to the response of the left pupil to light. Right pupillary reflex means reaction of the right pupil. In contrast, the terms "direct" and "consensual" refers to the side of the light source, relative to the side of the reacting pupil. A direct pupillary reflex is pupillary response from light that enters the ipsilateral eye. A consensual pupillary reflex is response of a pupil due to light that enters the contralateral eye. Thus there are four types of pupillary light reflexes, based on this terminology of absolute and relative laterality:

  1. "Left direct pupillary reflex" is the left pupil's response to light entering the ipsilateral eye, i.e. the left eye.
  2. "Left consensual pupillary reflex" is the left pupil's response to light entering the contralateral eye, i.e. the right eye.
  3. "Right direct pupillary reflex" is the right pupil's response to light entering the ipsilateral eye, i.e. the right eye.
  4. "Right consensual pupillary reflex" is the right pupil's response to light entering the contralateral eye, i.e. the left eye.

Anatomy of the pupillary light reflex neural pathway[edit]

The pupillary light reflex neural pathway on each side has an afferent limb and two efferent limbs. The afferent limb has nerve fibers running within the optic nerve, same as CN II. Each efferent limb has nerve fibers running along the oculomotor nerve, same as CN III. The afferent limb carries sensory input. Anatomically, the afferent limb consists of the retina, the optic nerve, and the pretectal nucleus in the midbrain, at level of superior colliculus. Ganglion cells of the retina project fibers through the optic nerve to the ipsilateral pretectal nucleus. The efferent limb is the pupillary motor output from the pretectal nucleus to the ciliary sphincter muscle of the iris. The pretectal nucleus projects crossed and uncrossed fibers to the ipsilateral and contralateral Edinger-Westphal nuclei, which are also located in the midbrain. Each Edinger-Westphal nucleus gives rise to preganglionic parasympathetic fibers which exit with CN III and synapse with postganglionic parasympathetic neurons in the ciliary ganglion. Postganglionic nerve fibers leave the ciliary ganglion to innervate the ciliary sphincter.[2] Each afferent limb has two efferent limbs, one ipsilateral and one contralateral. The ipsilateral efferent limb transmits nerve signals for direct light reflex of the ipsilateral pupil. The contralateral efferent limb causes consensual light reflex of the contralateral pupil.

4 Types of neurons in the pupillary light reflex pathway[edit]

The optic nerve, or more precisely, the photosensitive ganglion cells through the retinohypothalamic tract, is responsible for the afferent limb of the pupillary reflex - it senses the incoming light. The oculomotor nerve is responsible for the efferent limb of the pupillary reflex - it drives the muscles that constrict the pupil.[1]

Pathways in the Ciliary ganglion. Green = parasympathetic; Red = sympathetic; Blue = sensory
  1. Retina: The pupillary reflex pathway begins with the photosensitive retinal ganglion cells, which convey information via the optic nerve, the most peripheral, distal, portion of which is the optic disc. Some axons of the optic nerve connect to the pretectal nucleus of the upper midbrain instead of the cells of the lateral geniculate nucleus (which project to the primary visual cortex). These "intrinsic photosensitive ganglion cells" are also referred to as "melanopsin-containing" cells, and they influence circadian rhythms as well as the pupillary light reflex.
  2. Pretectal nuclei: From the neuronal cell bodies in some of the pretectal nuclei, axons synapse on (connect to) neurons in the Edinger-Westphal nucleus. Those neurons are the preganglionic cells with axons that run in the oculomotor nerves to the ciliary ganglia.
  3. Edinger-Westphal nuclei: Parasympathetic neuronal axons in the oculomotor nerve synapse on ciliary ganglion neurons.
  4. Ciliary ganglia: Short post-ganglionic ciliary nerves leave the ciliary ganglion to innervate the Iris sphincter muscle of the iris.[1]

Neural pathway schematics[edit]

Referring to the neural pathway schematic diagram, the entire pupillary light reflex system can be visualized as having eight neural segments, numbered 1 through 8. Odd-numbered segments 1, 3, 5, and 7 are on the left. Even-numbered segments 2, 4, 6, and 8 are on the right. Segments 3 and 4 are cross-over nerve fibers that occupy essentially the same space in the midbrain. Segments 3, 4, 5, and 6 are all located within a compact region within the midbrain.

Schematic diagram of pupillary light reflex neural pathway
  • Left direct light reflex involves neural segments 1, 5, and 7. Segment 1 is the afferent limb. Segments 5 and 7 form the efferent limb.
  • Left consensual light reflex involves neural segments 2, 4, and 7. Segment 2 is the afferent limb. Segments 4 and 7 form the efferent limb.
  • Right direct light reflex involves neural segments 2, 6, and 8. Segment 2 is the afferent limb. Segments 6 and 8 form the efferent limb.
  • Right consensual light reflex involves neural segments 1, 3, and 8. Segment 1 is the afferent limb. Segments 3 and 8 form the efferent limb.

The diagram may assist in localizing lesion within the pupillary reflex system by process of elimination, using light reflex testing results obtained by clinical examination.

Example of lesion localization based on pupillary light reflex testing results[edit]

For example, in a patient with abnormal left direct reflex and abnormal right consensual reflex (i.e. normal left consensual and right direct reflexes), which would produce a left Marcus Gunn pupil by physical examination:

  1. Left consensual reflex is normal, therefore segments 2, 4, and 7 are normal. Lesion is not located in any of these segments.
  2. Right direct reflex is normal, therefore segments 2, 6, and 8 are normal. Combining with earlier normals, segments 2, 4, 6, 7, and 8 are all normal.
  3. Remaining segments where lesion may be located are segments 1, 3, and 5. Possible combinations and permutations are: (a) segment 1 only, (b) segment 3 only, (c) segment 5 only, (d) combination of segments 1 and 3, (e) combination of segments 1 and 5, (f) combination of segments 3 and 5, and (g) combination of segments 1, 3, and 5.
  4. Options (b) and (c) are eliminated because isolated lesion in segment 3 alone or in segment 5 alone cannot produce the light reflex abnormalities in question.
  5. A single lesion anywhere along segment 1, the left afferent limb, which includes the left retina, left optic nerve, and left pretectal nucleus, can produce the light reflex abnormalities observed. Examples of segment 1 pathologies include left optic neuritis (inflammation or infection of the left optic nerve), detachment of left retina, and an isolated small stroke involving only the left pretectal nucleus. Therefore options (a), (d), (e), (f), and (g) are possible.
  6. A combined lesion in segments 3 and 5 as cause of defect is very unlikely. Microscopically precise strokes in the midbrain, involving the left pretectal nucleus, bilateral Edinger-Westphal nuclei, and their interconnecting fibers, could theoretically produce this result. Furthermore, segment 4 shares the same anatomical space in the midbrain as segment 3, therefore segment 4 will likely be affected if segment 3 is damaged. In this setting, it is very unlikely that left consensual reflex, which requires an intact segment 4, would be preserved. Therefore options (d), (f), and (g), which all includes segment 3, are eliminated. Remaining possible options are (a) and (e).
  7. Based on the above reasoning, the lesion must involve segment 1. Damage to segment 5 may accompany a segment 1 lesion, but is unnecessary for producing the abnormal light reflex results in this case. Option (e) involves a combined lesion of segments 1 and 5. Multiple sclerosis, which often affect multiple neurologic sites simultaneously, could potentially cause this combination lesion. In all probability, option (a) is the answer. Neuro-imaging, such as MRI scan, would be useful for confirmation of clinical findings.
A medical halogen penlight used to observe pupillary light reflex

Clinical significance[edit]

In addition to controlling the amount of light that enters the eye, the pupillary light reflex provides a useful diagnostic tool. It allows for testing the integrity of the sensory and motor functions of the eye.[1]

Under normal conditions, the pupils of both eyes respond identically to a light stimulus, regardless of which eye is being stimulated. Light entering one eye produces a constriction of the pupil of that eye, the direct response, as well as a constriction of the pupil of the unstimulated eye, the consensual response. Comparing these two responses in both eyes is helpful in locating a lesion.[1][3]

For example, a direct response in the right pupil without a consensual response in the left pupil suggests a problem with the motor connection to the left pupil (perhaps as a result of damage to the oculomotor nerve or Edinger-Westphal nucleus of the brainstem). Lack of response to light stimulation of the right eye if both eyes respond normally to stimulation of the left eye indicates damage to the sensory input from the right eye (perhaps to the right retina or optic nerve).[1]

Emergency room physicians routinely assess the pupillary reflex because it is useful for assessing brain stem function. Normally, pupils react (i.e. constrict) equally. Lack of the pupillary reflex or an abnormal pupillary reflex can be caused by optic nerve damage, oculomotor nerve damage, brain stem death and depressant drugs, such as barbiturates.[citation needed]

For normal pupillary light reflex, both pupils constrict simultaneously when light is shone into either eye. For example, if light is shone into left eye only, left pupil constriction is a direct pupillary light reflex, and simultaneous right pupil constriction is a consensual pupillary light reflex. Therefore light shone into one eye causes ipsilateral direct pupillary light reflex and contralateral consensual pupillary light reflex. On testing light reflex for each eye, several patterns are possible.[4]

  • Optic nerve damage on one side: (Example in parens.: Left optic nerve, CN II, is completely transected somewhere in its course between retina and optic chiasma, therefore the left afferent limb is damaged. The rest of the pupillary light reflex neural pathway on both sides are otherwise intact.)
    • The ipsilateral direct reflex is lost. (Example: When the left eye is stimulated by light, neither pupils constrict. Afferent signals from the left eye cannot pass through the transected left optic nerve to reach the intact efferent limb on the left.)
    • The contralateral consensual reflex is lost. (Example: When the left eye is stimulated by light, neither pupils constrict. Afferent signals from the left eye cannot pass through the transected left optic nerve to reach the intact efferent limb on the right.)
    • The contralateral direct reflex is intact. (Example: Direct light reflex of right pupil involves the right optic nerve and right oculomotor nerve, which are both intact.)
    • The ipsilateral consensual reflex is intact. (Example: Consensual light reflex of left pupil involves the right optic nerve and left oculomotor nerve, which are both undamaged.)
  • Oculomotor nerve damage on one side: (Example in parens: Left oculomotor nerve, CN III, is transected, therefore the left efferent limb is damaged.)
    • The ipsilateral direct reflex is lost. (Example: When the left eye is stimulated by light, left pupil does not constrict, because the efferent signals cannot pass from midbrain to the left pupillary sphincter.)
    • The contralateral consensual reflex is intact. (Example: When the left eye is stimulated by light, the right pupil constricts, because the afferent limb on the left and the efferent limb on the right are both intact )
    • The contralateral direct reflex is intact. (Example: When light is shone into right eye, right pupil constricts. Direct reflex of the right pupil is unaffected, The right afferent limb, right CN II, and the right efferent limb, right CN III, are both intact.)
    • The ipsilateral consensual reflex is lost. (Example: When the right eye is stimulated by light, left pupil does not constrict consensually. Right afferent limb is intact, but left efferent limb, left CN III, is damaged.)

Cognitive influences[edit]

The pupillary response to light is not purely reflexive, but is modulated by cognitive factors, such as attention, awareness, and the way visual input is interpreted. For example, if a bright stimulus is presented to one eye, and a dark stimulus to the other eye, perception alternates between the two eyes (i.e. binocular rivalry): Sometimes the dark stimulus is perceived, sometimes the bright stimulus, but never both at the same time. Using this technique, it has been shown the pupil is smaller when a bright stimulus dominates awareness, relative to when a dark stimulus dominates awareness.[5] [6] This shows that the pupillary light reflex is modulated by visual awareness. Similarly, it has been shown that the pupil constricts when you covertly (i.e. without looking at) pay attention to a bright stimulus, compared to a dark stimulus, even when visual input is identical.[7][8][9] Moreover, the magnitude of the pupil light reflex following a distracting probe is strongly correlated with the extent to which the probe captures visual attention and interferes with task performance.[10] This shows that the pupillary light reflex is modulated by visual attention and trial-by-trial variation in visual attention. Finally, a picture that is subjectively perceived as bright (e.g. a picture of the sun), elicits a stronger pupillary constriction than an image that is perceived as less bright (e.g. a picture of an indoor scene), even when the objective brightness of both images is equal.[11] [12] This shows that the pupillary light reflex is modulated by subjective (as opposed to objective) brightness.

A Mathematical Description[edit]

Pupillary Light Reflex is modeled as a physiologically-based non-linear delay differential equation that describes the changes in the pupil diameter as a function of the environment lighting:[13]

where is the pupil diameter measured in millimeters and is the luminous intensity reaching the retina in a time , which can be described as : luminance reaching the eye in lumens/mm2 times the pupil area in mm2. is the pupillary latency, a time delay between the instant in which the light pulse reaches the retina and the beginning of iridal reaction due nerve transmission, neuro-muscular excitation and activation delays. , and are the derivatives for the function, pupil diameter and time .

Since the pupil constriction velocity is approximately 3 times faster than (re)dilation velocity,[14] different step sizes in the numerical solver simulation must be used:

where and are respectively the for constriction and dilation measured in milliseconds, and are respectively the current and previous simulation times (times since the simulation started) measured in milliseconds, is a constant that affects the constriction/dilation velocity and varies among individuals. The higher the value, the smaller the time step used in the simulation and, consequently, the smaller the pupil constriction/dilation velocity.

In order to improve the realism of the resulting simulations, the hippus effect can be approximated by adding small random variations to the environment light (in the range of 0.05 Hz to 0.3 Hz).[15]

See also[edit]

References[edit]

  1. ^ a b c d e f Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed. Sinauer Associates. pp. 290–1. ISBN 978-0-87893-697-7. 
  2. ^ Kaufman, Paul L.; Levin, Leonard A.; Alm, Albert (2011). Adler's Physiology of the Eye. Elsevier Health Sciences. p. 508. ISBN 0-323-05714-4. 
  3. ^ "Cranial Nerve III—Oculomotor Nerve". yale.edu. Retrieved 2008-07-27. 
  4. ^ Colman, Andrew M. (August 2001). A Dictionary of Psychology. Oxford University Press, USA. ISBN 0-19-866211-4. 
  5. ^ Harms, H. (1937). "Ort und Wesen der Bildhemmung bei Schielenden". Graefe's Archive for Clinical and Experimental Ophthalmology. 138 (1): 149–210. doi:10.1007/BF01854538. 
  6. ^ Naber M., Frassle, S. Einhaüser W. (2011). "Perceptual rivalry: Reflexes reveal the gradual nature of visual awareness". PLoS ONE. 6 (6): e2011. doi:10.1371/journal.pone.0020910. PMC 3109001free to read. PMID 21677786. 
  7. ^ Binda P.; Pereverzeva M.; Murray S.O. (2013). "Attention to bright surfaces enhances the pupillary light reflex". Journal of Neuroscience. 33 (5): 2199–2204. doi:10.1523/jneurosci.3440-12.2013. PMID 23365255. 
  8. ^ Mathôt S., van der Linden, L. Grainger, J. Vitu, F. (2013). "The pupillary response to light reflects the focus of covert visual attention". PLoS ONE. 8 (10): e78168. doi:10.1371/journal.pone.0078168. PMC 3812139free to read. PMID 24205144. 
  9. ^ Mathôt S., Dalmaijer E., Grainger J., Van der Stigchel, S. (2014). "The pupillary light response reflects exogenous attention and inhibition of return" (PDF). Journal of Vision. 14 (14): e7. doi:10.1167/14.14.7. PMID 25761284. 
  10. ^ Ebitz R.; Pearson J.; Platt M. (2014). "Pupil size and social vigilance in rhesus macaques". Frontiers in Neuroscience. 8 (100). doi:10.3389/fnins.2014.00100. PMID 24834026. 
  11. ^ Binda P.; Pereverzeva M.; Murray S.O. (2013). "Pupil constrictions to photographs of the sun". Journal of Vision. 13 (6): e8. doi:10.1167/13.6.8. PMID 23685391. 
  12. ^ Laeng B.; Endestad T. (2012). "Bright illusions reduce the eye's pupil". Proceedings of the National Academy of Sciences. 109 (6): 2162–2167. doi:10.1073/pnas.1118298109. PMC 3277565free to read. PMID 22308422. 
  13. ^ Pamplona, Vitor F.; Oliveira, Manuel M.; Baranoski, Gladimir V. G. (1 August 2009). "Photorealistic models for pupil light reflex and iridal pattern deformation". ACM Transactions on Graphics. 28 (4): 1–12. doi:10.1145/1559755.1559763. 
  14. ^ Ellis, C. J. (1981). "The pupillary light reflex in normal subjects". British Journal of Ophthalmology. 65 (11): 754–759. doi:10.1136/bjo.65.11.754. PMC 1039657free to read. PMID 7326222. 
  15. ^ Stark, L (August 1963). "Stability, Oscillations, and Noise in the Human Pupil Servomechanism.". Boletin del Instituto de Estudios Medicos y Biologicos, Universidad Nacional Autonoma de Mexico. 21: 201–22. PMID 14122256. 

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