Pustular psoriasis

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

The term pustular psoriasis is used for a heterogeneous group of diseases that share pustular skin characteristics.[1]

Pustular Psoriasis
Psoriasis manum.jpg
Severe pustular psoriasis.

Signs and symptoms[edit]

Characteristics may vary according to the subtype of pustular psoriasis. For example, it can be localized, commonly to the hands and feet (localized pustular psoriasis), or generalized with widespread patches appearing randomly on any part of the body (generalized pustular psoriasis).[2][3] However, all forms of pustular psoriasis share in common the presence of red and tender blotchy skin covered with pustules.[1]

Pustular psoriasis can be localized, commonly to the hands and feet (palmoplantar pustulosis), or generalized with widespread patches occurring randomly on any part of the body. Acrodermatitis continua is a form of localized psoriasis limited to the fingers and toes that may spread to the hands and feet.[4] Pustulosis palmaris et plantaris is another form of localized pustular psoriasis similar to acrodermatitis continua with pustules erupting from red, tender, scaly skin found on the palms of the hands and the soles of the feet.[1]

Generalized pustular psoriasis (GPP) is also known as (von Zumbusch) acute generalized pustular psoriasis in acute cases, and as impetigo herpetiformis during pregnancy.[3][5] GPP is a rare and severe form of psoriasis that may require hospitalization. This form of psoriasis is characterized by an acute onset of numerous pustules on top of tender red skin. This skin eruption is often accompanied by a fever, muscle aches, nausea, and an elevated white blood cell count.[1] Annular pustular psoriasis (APP), a rare form of GPP, is the most common type seen during childhood.[6] APP tends to occur in women more frequently than in men, and is usually less severe than other forms of generalized pustular psoriasis such as impetigo herpetiformis.[6] This form of psoriasis is characterized by ring-shaped plaques with pustules around the edges and yellow crusting.[6] APP most often affects the torso, neck, arms, and legs.[6]



Pustular psoriasis is classified into two major forms: localized and generalized pustular psoriasis.[1] Within these two categories there are several variants:

Classification of Localized and Generalized Pustular Psoriasis
Localized pustular psoriasis
Generalized pustular psoriasis


injection of methotrexate


  1. ^ a b c d e Raychaudhuri, Smriti K.; Maverakis, Emanual; Raychaudhuri, Siba P. (2014-04-01). "Diagnosis and classification of psoriasis". Autoimmunity Reviews. 13 (4–5): 490–495. doi:10.1016/j.autrev.2014.01.008. ISSN 1873-0183. PMID 24434359.
  2. ^ Kawada, Akira; Tezuka, Tadashi; Nakamizo, Yoshio; Kimura, Hideto; Nakagawa, Hidemi; Ohkido, Muneo; Ozawa, Akira; Ohkawara, Akira; Kobayashi, Hitoshi (2003). "A survey of psoriasis patients in Japan from 1982 to 2001". Journal of Dermatological Science. 31 (1): 59–64. doi:10.1016/s0923-1811(02)00142-1. PMID 12615365.
  3. ^ a b Baker, Harvey; Ryan, Terence J. (1968-12-01). "Generalized Pustular Psoriasis". British Journal of Dermatology. 80 (12): 771–793. doi:10.1111/j.1365-2133.1968.tb11947.x. ISSN 1365-2133. PMID 4236712.
  4. ^ Rosenberg, Benjamin E.; Strober, Bruce E. (2004-11-30). "Acrodermatitis continua". Dermatology Online Journal. 10 (3): 9. ISSN 1087-2108. PMID 15748579.
  5. ^ Oumeish, Oumeish Youssef; Parish, Jennifer L. (2006). "Impetigo herpetiformis". Clinics in Dermatology. 24 (2): 101–104. doi:10.1016/j.clindermatol.2005.10.009. PMID 16487882.
  6. ^ a b c d Naik HB, Cowen EW (July 2013). "Autoinflammatory pustular neutrophilic diseases". Dermatol Clin. 31 (3): 405–25. doi:10.1016/j.det.2013.04.001. PMC 3703099. PMID 23827244.

External links[edit]