Pustulosis palmaris et plantaris

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Pustulosis palmaris et plantaris
Other namesPustulosis of palms and soles,[1] Palmoplantar pustulosis, Persistent palmoplantar pustulosis, Pustular psoriasis of the Barber type, and Pustular psoriasis of the extremities
Pustulosis palmaris et plantaris
SpecialtyDermatology Edit this on Wikidata
Differential diagnosisSAPHO syndrome

Pustulosis palmaris et plantaris is a chronic recurrent pustular dermatosis (that is, a pustulosis or pustular psoriasis) localized on the palms and soles only, characterized histologically by intraepidermal pustules filled with neutrophils.[2]: 411, 628 [3]: 204  It can occur as part of the SAPHO syndrome.[4]


Systematic reviews show evidence to support the use of systemic retinoids alone and in combination with photochemotherapy to improve symptoms of chronic palmoplantar pustulosis, with a combination more effective than one alone. There is also evidence to support topical steroids under hydrocolloid occlusion dressings, low dose ciclosporin, tetracyclines, and Grenz-Ray Therapy. There is no evidence to support the use of hydroxyurea in chronic palmoplantar pustulosis.[5]

Treatment with guselkumab, an anti–interleukin 23 monoclonal antibody has shown a decrease in the size of the area affected and severity.[6]

See also[edit]


  1. ^ Rapini RP, Bolognia JL, Jorizzo JL (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ^ Freedberg IM, Fitzpatrick TB (2003). Fitzpatrick's Dermatology in General Medicine (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  3. ^ James W, Berger T, Elston D (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. ISBN 0-7216-2921-0..
  4. ^ Matzaroglou C, Velissaris D, Karageorgos A, Marangos M, Panagiotopoulos E, Karanikolas M (November 2009). "SAPHO Syndrome Diagnosis and Treatment: Report of Five Cases and Review of the Literature". The Open Orthopaedics Journal. 3: 100–6. doi:10.2174/1874325000903010100. PMC 2790148. PMID 19997538.
  5. ^ Chalmers, Robert; Hollis, Sally; Leonardi-Bee, Jo; Griffiths, Christopher EM; Marsland Bsc MRCP, Alexander (2006-01-25). "Interventions for chronic palmoplantar pustulosis". Cochrane Database of Systematic Reviews. 2016 (1): CD001433. doi:10.1002/14651858.cd001433.pub2. ISSN 1465-1858. PMC 8958875. PMID 16437433. S2CID 26948658.
  6. ^ Terui T, Kobayashi S, Okubo Y, Murakami M, Zheng R, Morishima H, et al. (July 2019). "Efficacy and Safety of Guselkumab in Japanese Patients With Palmoplantar Pustulosis: A Phase 3 Randomized Clinical Trial". JAMA Dermatology. 155 (10): 1153. doi:10.1001/jamadermatol.2019.1394. PMC 6613288. PMID 31268476.

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