Pwo DNA polymerase

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Symbol pol

Pwo polymerase is a thermostable DNA polymerase used for the polymerase chain reaction. The abbreviation stands for Pyrococcus woesei, a thermophilic archaeon, from which this polymerase was isolated. This polymerase breaks when reaching erroneous uracil in DNA from the chain extension and, through this readahead function, fewer defective DNA clones are synthesized. It is used much less than the usual Taq or Pfu polymerases.[1]


  1. ^ Amir Ghasemi; Ali Hatef Salmanian; Nourkhoda Sadeghifard; Amir Ahmad Salarian; Mohammad Khalifeh Gholi (2011). "Cloning, expression and purification of Pwo polymerase from Pyrococcus woesei". Iran J Microbiol. 3 (3): 118–122. PMC 3279813Freely accessible. PMID 22347593.