Pyrroline-2-carboxylate reductase

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pyrroline-2-carboxylate reductase
Identifiers
EC number1.5.1.1
CAS number9029-16-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a pyrroline-2-carboxylate reductase (EC 1.5.1.1) is an enzyme that catalyzes the chemical reaction

L-proline + NAD(P)+ 1-pyrroline-2-carboxylate + NAD(P)H + H+

The 3 substrates of this enzyme are L-proline, NAD+, and NADP+, whereas its 4 products are 1-pyrroline-2-carboxylate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD(P)+ 2-oxidoreductase. This enzyme is also called Delta1-pyrroline-2-carboxylate reductase. This enzyme participates in lysine degradation and arginine and proline metabolism.

References[edit]

  • Meister A, Radhakrishnan AN, Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline". J. Biol. Chem. 229 (2): 789–800. PMID 13502341.