Pyrroline-5-carboxylate reductase
| pyrroline-5-carboxylate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Pyrroline-5-carboxylate reductase 1 decamer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.5.1.2 | ||||||||
| CAS no. | 9029-17-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, pyrroline-5-carboxylate reductase (EC 1.5.1.2) is an enzyme that catalyzes the chemical reaction
-1-pyrroline-5-carboxylic_acid.svg)
The three substrates of this enzyme are (S)-1-pyrroline-5-carboxylic acid, reduced nicotinamide adenine dinucleotide (NADH), and a proton. Its products are L-proline and oxidised (NAD+). Nicotinamide adenine dinucleotide phosphate can be used as an alternative cofactor.[1][2][3][4][5]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD(P)+ 5-oxidoreductase. Other names in common use include proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, and L-proline-NAD(P)+ 5-oxidoreductase. This enzyme participates in arginine and proline metabolism.[1]
Structural studies
[edit]As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB: 2AHR, PDB: 2GER, PDB: 2GR9, PDB: 2GRA, and PDB: 2IZZ.
Human genes
[edit]References
[edit]- 1 2 Enzyme 1.5.1.2 at KEGG Pathway Database.
- ↑ Adams E; Goldstone A (1960). "Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Delta1-pyrroline-3-hydroxy-5-carboxylate". The Journal of Biological Chemistry. 235 (12): 3499–3503. doi:10.1016/S0021-9258(18)64497-7. PMID 13681369.
- ↑ Meister A, Radhakrishnan AN, Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline". The Journal of Biological Chemistry. 229 (2): 789–800. doi:10.1016/S0021-9258(19)63684-7. PMID 13502341.
- ↑ Smith ME; Greenberg DM (1956). "Characterization of an enzyme reducing pyrroline-5-carboxylate to proline". Nature. 177 (4520): 1130. Bibcode:1956Natur.177.1130S. doi:10.1038/1771130a0. PMID 13334497. S2CID 4298013.
- ↑ Yura T; Vogel HJ (1959). "Pyrroline-5-carboxylate reductase of Neurospora crassa: partial purification and some properties". The Journal of Biological Chemistry. 234 (2): 335–338. doi:10.1016/S0021-9258(18)70299-8. PMID 13630905.
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