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Q-16 or Q16 may refer to:
- Q16 (New York City bus), a bus route in Queens
- Honeywell RQ-16 T-Hawk, an American drone built by Honeywell
- Frankfort OQ-16, an American drone built by the Frankfort Sailplane Company
- The quaternion group of order 16
disambiguation page lists articles associated with the same title formed as a letter-number combination.
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