The district was split from Larkana District in December 2004. There was some controversy over the name of the district, with Qambar being favoured initially, but after protests from residents of Shahdadkot, it was renamed to Qambar-Shahdadkot District. The headquarters of the district is Qambar city.
Administratively it is subdivided into seven Talukas namely Qambar, Shahdadkot, Warah, Miro khan, Nasirabad, Qubo Saeed Khan and Sajawal. The district government comprises seven groups of offices i.e. No health, education, works and services, no finance and planning, No community development, revenue and agriculture besides district administration comprising a District Nazim (mayor), Naib Nazim (deputy mayor) and District Coordination Officer.