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Quack may refer to:

  • Quack (comics), an independent-comics series published by Star Reach in the 1970s
  • Quack (horse), an American Thoroughbred racehorse
  • Quack (sound), onomatopoeia for the sound made by ducks
  • Quack (album), an album by the Canadian group Duck Sauce
  • Quack grass, a type of grass
  • Quack.com, a company based in Silicon Valley
  • O. K. Quack, a character in the Scrooge McDuck universe
  • A person who practices quackery (the promotion of unproven or fraudulent medical practices)