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Clinical data
Other namesRo 13-6438
Routes of
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass235.67 g·mol−1
3D model (JSmol)

Quazinone (Dozonone) is a cardiotonic and vasodilator drug which was developed and marketed in the 1980s for the treatment of heart disease.[1][2][3][4][5] It acts as a selective PDE3 inhibitor.[6][7] It is no longer available.[1]

See also[edit]


  1. ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 978-0-412-46630-4.
  2. ^ Eigenmann R, Gerold M, Holck M (1984). "Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties". Journal of Cardiovascular Pharmacology. 6 (3): 511–9. doi:10.1097/00005344-198405000-00021. PMID 6202980.
  3. ^ Holck M, Thorens S, Muggli R, Eigenmann R (1984). "Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties". Journal of Cardiovascular Pharmacology. 6 (3): 520–30. doi:10.1097/00005344-198405000-00022. PMID 6202981.
  4. ^ Belz GG, Stern HC, Butzer R (1985). "Dose-response following single administrations of a new cardiac performance enhancer RO 13-6438 in normal volunteers". Journal of Cardiovascular Pharmacology. 7 (1): 86–90. doi:10.1097/00005344-198501000-00014. PMID 2580156.
  5. ^ Daly PA, Chatterjee K, Viquerat CE, et al. (June 1985). "RO13-6438, a new inotrope-vasodilator: systemic and coronary hemodynamic effects in congestive heart failure". The American Journal of Cardiology. 55 (13 Pt 1): 1539–44. doi:10.1016/0002-9149(85)90969-5. PMID 4003296.
  6. ^ Osinski MT, Schrör K (August 2000). "Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: role of protein kinase A in vascular smooth muscle cell mitogenesis". Biochemical Pharmacology. 60 (3): 381–7. doi:10.1016/S0006-2952(00)00328-2. PMID 10856433.
  7. ^ Denis D, Riendeau D (February 1999). "Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes". European Journal of Pharmacology. 367 (2–3): 343–50. doi:10.1016/S0014-2999(98)00987-X. PMID 10079010.

External links[edit]

  • Media related to Quazinone at Wikimedia Commons