Quinbolone

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Quinbolone
Quinbolone.png
Quinbolone molecule ball.png
Clinical data
Trade names Anabolicum, Anabolvis
Synonyms MK-810; Δ1-Testosterone 17β-cyclopent-1-enyl enol ether; 1-Dehydrotestosterone 17β-cyclopent-1-enyl ether; 17β-(1-Cyclopenten-1-yloxy)androsta-1,4-dien-3-one; Androsta-1,4-dien-17β-ol-3-one 17β-(1-cyclopent-1-ene)
Pregnancy
category
  • X
Routes of
administration
By mouth[1]
ATC code
Legal status
Legal status
Pharmacokinetic data
Metabolism Liver
Excretion Urine
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
Formula C24H32O2
Molar mass 352.516 g/mol
3D model (JSmol)
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Quinbolone (INN, USAN), sold under the brand names Anabolicum and Anabolvis, is an androgen and anabolic steroid (AAS) which was previously marketed in Italy.[2][3][4] It was developed by Parke-Davis[3] as a viable orally-administered AAS with little or no liver toxicity.[1]

Pharmacology[edit]

Most orally administered anabolic steroids function by having an alkylated 17α-carbon atom, which prevents first-pass metabolism by the liver.[citation needed] This approach however results in the AAS having hepatotoxicity.[citation needed] Quinbolone is not 17α-alkylated; instead it has increased oral bioavailability due to its cyclopentenyl ether group.[citation needed] After ingestion, the inactive quinbolone is transformed into boldenone.[1]

Quinbolone itself has very few androgenic effects, and most of what it does have are a result of its conversion to boldenone and its metabolites.[1][5][additional citation(s) needed] Because of high doses necessary for androgenic effects, cost and inconvenience meant that quinbolone never proved to be commercially successful, and its clinical applications were fulfilled by alternative, more effective, AAS.[citation needed] Its illicit usage in bodybuilding and athletics likewise proved limited, though drug tests are still used to detect its metabolites as it remains a banned substance for most competitive sports.[citation needed]

Quinbolone, via boldenone, can be transformed into estrogens, and hence may have some estrogenic activity.[5]

Side effects[edit]

Chemistry[edit]

Quinbolone, also known as δ1-testosterone 17β-cyclopent-1-enyl enol ether or as androsta-1,4-dien-17β-ol-3-one 17β-(1-cyclopent-1-ene) enol ether, is a synthetic androstane steroid and a derivative of testosterone.[2][3] It is the C17β cyclopentyl enol ether of boldenone1-testosterone).[2][3] A related AAS is boldenone undecylenate1-testosterone 17β-undec-10-enoate).[2][3]

Synthesis[edit]

Quinbolone can be prepared from testosterone. Dehydrogenation using DDQ forms boldenone. Reaction with 1,1-dimethoxycyclopentane followed by heating to eliminate methanol gives quinbolone.

Quinbolone synthesis:[6]

History[edit]

Quinbolone was described as early as 1962.[7] It was marketed in Italy by Parke-Davis.[3]

References[edit]

  1. ^ a b c d Galletti F, Gardi R (July 1971). "Metabolism of 1-dehydroandrostanes in man. I. Metabolism of 17-hydroxyandrosta-1,4-dien-3-one, 17-cyclopent-1'-enyloxyandrosta-1,4-dien-3-one (quinbolone) and androsta-1,4-diene-3,17-dione (1)". Steroids. 18 (1): 39–50. PMID 5098537. 
  2. ^ a b c d J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1056–. ISBN 978-1-4757-2085-3. 
  3. ^ a b c d e f Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 904–. ISBN 978-3-88763-075-1. 
  4. ^ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 243–. ISBN 978-94-011-4439-1. 
  5. ^ a b M. Finkelstein; A. Klopper; C. Conti (22 October 2013). Research on Steroids: Proceedings of the Fourth Meeting of the International Study Group for Steroid Hormones. Elsevier Science. pp. 121–. ISBN 978-1-4831-5403-9. 
  6. ^ Ercoli et al., Chem. Ind. (London) 1962, 1284.
  7. ^ Ercoli, A., Gardi, R., & Vitali, R. (1962). Steroid-17β-yl acetals and enol ethers. New classes of orally and parenterally active hormonal derivatives. Chemistry & Industry, (28), 1284-1285. https://scholar.google.com/scholar?cluster=7055026650056976887