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|Chemical and physical data|
|Molar mass||364.52 g/mol|
|3D model (Jmol)|
|(what is this?)|
Quinestrol (INN, USAN, BAN) (brand names Agalacto-Quilea, Basaquines, Eston, Estrovis, Estrovister, Plestrovis, Qui-Lea), also known as ethinylestradiol 3-cyclopentyl ether (EE2CPE), is a synthetic, steroidal estrogen used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer. It is a prodrug of ethinylestradiol (with cyclopentanol also being formed) with no intrinsic estrogenic activity of its own, and has a very long terminal half-life of more than 120 hours due to enhanced lipophilicity. Because of its much longer terminal half-life, quinestrol is two to three times as potent as ethinylestradiol. The drug was marketed as Estrovis in the United States by Parke Davis and as Qui-Lea in Argentina, but is reportedly not currently marketed. However, it does appear to be available as an oral contraceptive in combination with progestins in Argentina and China. Quinestrol was described in the literature in 1967.
- Ethinylestradiol sulfonate
- Estradiol cypionate
- Quingestanol acetate
- J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 522–. ISBN 978-1-4757-2085-3.
- I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 243–. ISBN 978-94-011-4439-1.
- Christoph Zink (1 January 1988). Dictionary of Obstetrics and Gynecology. Walter de Gruyter. pp. 204–. ISBN 978-3-11-085727-6.
- Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 905–. ISBN 978-3-88763-075-1.
- Michael Oettel; Ekkehard Schillinger (6 December 2012). Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. pp. 248–. ISBN 978-3-642-60107-1.
- A. Wayne Meikle (1 June 1999). Hormone Replacement Therapy. Springer Science & Business Media. pp. 381–. ISBN 978-1-59259-700-0.
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