The Quixote Center achieved prominence in its support of the ideals of the Sandinista government of Nicaragua in the 1980s. The Center raised more than $100 million in humanitarian aid for the Nicaraguan government. Although the Center did not officially take sides during the revolution in Nicaragua, its work was described by The New York Times as "intensely political" and the aid it sent went largely to assist victims of the Contra War. A leader at the Center described U.S. efforts in Nicaragua as a "policy of terrorism." Some critics accused the Center of following a Marxist agenda and the United States Department of the Treasury investigated allegations that Quixote Center had smuggled guns, but no charges were brought and leaders of the Center described the allegations as politically motivated.
The Center has actively opposed the death penalty.
-  Quixote Center webpage
- "Rev. William R. Callahan Dies at 78; Dissident Who Challenged Vatican," Douglas Martin, New York Times, July 10, 2010, 
- "A Mayoral Hopeful Now, de Blasio Was Once a Young Leftist," Javier Hernandez, New York Times, 
- "Ideas & Trends; Death and the White House," Jim Yardley, New York Times, Dec. 17, 2000 
- "A Mayoral Hopeful Now, de Blasio Was Once a Young Leftist," Javier Hernandez, New York Times,