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R50 may refer to :
- R50 road (South Africa)
- R50 (Mini), an internal designation for a Mini car model produced between 2001 and 2006
- R50 (Nissan Pathfinder), a second generation of car
- R50: Very toxic to aquatic organisms, a risk phrase
- BMW R50, a motorcycle
- HMS Venus (R50), a British Royal Navy World War II V-class destroyer
- ThinkPad R50 series, a laptop computer model
- Touareg R50, a car
- Line R50, a commuter rail service on the Llobregat–Anoia Line, in Barcelona, Catalonia, Spain
- R50 refrigerant; methane
- R50, one of the Wheels of Excellence range of Ferris wheel designs by Ronald Bussink, acquired by Vekoma in 2008
- a Samsung Sens laptop computer model
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